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- W2017803832 abstract "Nucleotides do not penetrate cells at a sufficient rate to realize their therapeutic potential. To overcome this limitation we have envisaged acyl nucleodi(tri)phosphates (ND(T)Ps) as suitable membrane permeable prodrugs because a) preliminary experiences have shown that these compounds are preferably cleaved at their mixed carboxylic phosphoric bond to generate the corresponding carboxylic group (3) and nucleotides (2)1, and b) the potential modification of the acyl group R allows to vary the lipophilicity of the acyl nucleotide derivative." @default.
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- W2017803832 title "Synthesis of acylphosphates of purine ribonucleosides" @default.
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