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- W2017804026 abstract "Although more than 20 years have elapsed since Curtis, Krnjević, Phillis and Watkins1,2 showed that the acidic amino acids glutamate and aspartate produce excitation of central neurones, until recently the electrophysiological and pharmacological evidence for the role of these substances as neurotransmitters has been weak. However, during the past three years the situation has changed dramatically with the development of new antagonists for the excitatory amino acids3, the refinement of the in-vitro brain slice preparation and the improvements in intracellular recording techniques4. In the hippocampus, a brain structure well suited to in-vitro studies and where excitatory pathways have long been thought to use an amino acid transmitter, the application of these new compounds and techniques has been particularly successful. Thus it has been possible to use vertebrate neurones for the first time to measure synaptic currents, to compare the reversal potential of the EPSPs and of the excitatory amino acids, and to analyse pharmacological antagonism at the intracellular level. The synaptic receptors have been partially characterized while the exact nature of the endogenous excitatory transmitter must still await the development of more selective antagonists." @default.
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- W2017804026 date "1985-01-01" @default.
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- W2017804026 title "Excitatory amino acids in the hippocampus: synaptic physiology and pharmacology" @default.
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- W2017804026 doi "https://doi.org/10.1016/0166-2236(85)90011-6" @default.
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