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- W2017804356 abstract "Summary A study of the effect of acetylcholine and epinephrine has led to the following conception of fibrillation. Cardiac muscle is unlike skeletal muscle and nerve in having a long action potential; that is to say, when cardiac muscle is stimulated it remains inexcitable for a long time, whereas skeletal muscle and nerve recover their excitability very quickly. If the factors which cause or facilitate fibrillation are examined, they are all factors which reduce the duration of the action potential, and thus diminish the period of inexcitability. The conclusion seems certain that the purpose of the long action potential in cardiac muscle is to prevent fibrillation among fibers which are out of phase. Stimuli sent in rapid succession probably do not travel at a uniform rate, and thus fibers even if adjacent may not remain in phase. When a fiber contracts there is spread of excitation from it. This excitation has no effect on adjacent fibers which are not exactly in phase if the action potential is of normal duration , for those fibers are depolarized. The excitation, however, causes fibrillation if the action potential is short, for adjacent fibers out of phase are excitable, because they are already repolarized. Fibrillation is a condition in which fibers are continually contracting out of phase because they are stimulating one another." @default.
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- W2017804356 modified "2023-09-24" @default.
- W2017804356 title "The relation of the autonomic nervous system to cardiac arrhythmias" @default.
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- W2017804356 doi "https://doi.org/10.1016/s0033-0620(60)80069-2" @default.
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