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• W2017804847 abstract "1 The action and interaction of noradrenaline (NA), 5-hydroxytryptamine (5-HT) and the sympathetic innervation was studied in the isolated taenia of the guinea-pig caecum. 2 Addition of 5-HT led to a contraction of the taenia while addition of NA or perivascular nerve stimulation resulted in relaxation. Responses to 5-HT or perivascular nerve stimulation were abolished by tetrodotoxin. Tetrodotoxin did not affect responses to applied NA. Hexamethonium and hyoscine converted the 5-HT response to a relaxation and augmented the relaxation which followed low frequency perivascular nerve stimulation. Hexamethonium and hyoscine did not affect the dose-response relationship for NA. 3 Fatigue of mechanical responses of the taenia to perivascular nerve stimulation was accelerated when nerves were stimulated in the presence of 5-HT or α-methyl-p-tyrosine (α-MPT). These two agents were additive in this action. 4 Reserpine, 6-hydroxydopamine and α-MPT all reduced the NA content of the taenia. However, only after 6-hydroxydopamine could adrenergic activity be related to NA content. 5 Segments of taenia were incubated with either tritiated NA or 5-HT. An increased rate of release of radioactivity followed perivascular nerve stimulation after incubation with either substance. This release did not occur when tissue was taken from animals given reserpine or 6-hydroxydopamine. 6 It is concluded that 5-HT activates neural elements exclusively while NA has a direct effect on smooth muscle. 5-HT can apparently be taken up by adrenergic axons, and appears to enter the releasable neurotransmitter pool. Since none of the actions characteristic of 5-HT are seen when it is released by adrenergic axons as a false neurotransmitter, the released amine probably fails to reach neuronal receptors for 5-HT." @default.
• W2017804847 created "2016-06-24" @default.
• W2017804847 creator A5019329770 @default.
• W2017804847 creator A5067946532 @default.
• W2017804847 date "1972-07-01" @default.
• W2017804847 modified "2023-09-26" @default.
• W2017804847 title "Studies of the interaction of 5-hydroxytryptamine and the perivascular innervation of the guinea-pig caecum" @default.
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• W2017804847 doi "https://doi.org/10.1111/j.1476-5381.1972.tb08098.x" @default.
• W2017804847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1666164" @default.
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