FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017805604> ?p ?o ?g. }

• W2017805604 endingPage "628" @default.
• W2017805604 startingPage "622" @default.
• W2017805604 abstract "We studied 210 unselected patients with acute myeloid leukaemia (AML) for MLL abnormalities. Twenty-seven patients (13%) with rearranged MLL genes were identified by means of Southern blot analysis. An MLL-AF6 fusion transcript was detected in six patients by a reverse transcriptase polymerase chain reaction (RT-PCR) for the MLL-AF6 translocation. Sequence analysis showed fusion of MLL exon 7 as well as exon 6 (two patients) or MLL exon 6 as well as exon 5 (four patients) to AF6 exon 2. In only three patients could the t(6;11) also be identified by cytogenetic and/or fluorescence in situ hybridization (FISH) analysis. The MLL-AF6-positive patients were monitored by RT-PCR for a period of 6-33 months. Complete haematological remission (CR) was achieved in all six cases, but was short in 5/6 patients (range 2.6-8.3 months). In these five patients, the MLL-AF6 transcripts were detected in every sample tested after induction and consolidation chemotherapy. One patient received autologous bone marrow transplantation (BMT) which also did not lead to PCR negativity. Intensive salvage therapy was unable to induce a second remission in the relapsed patients. One of the six MLL-AF6-positive patients achieved a molecular CR. He is still in CR at 33 months after diagnosis. Survival analysis indicates a poor prognosis in MLL-AF6-positive patients. The median event-free survival was 6.8 months, the median overall survival 15 months. Persistent PCR positivity was consistently associated with relapse. Thus, RT-PCR provides a valuable and sensitive tool for the identification of t(6;11)-positive AML and the monitoring of response to treatment in these patients. The results of RT-PCR may be useful to evaluate therapeutic procedures and to make treatment decisions, which will enable molecular remissions to be achieved and improve the clinical outcome in this group of patients." @default.
• W2017805604 created "2016-06-24" @default.
• W2017805604 creator A5020002610 @default.
• W2017805604 creator A5033965282 @default.
• W2017805604 creator A5034222353 @default.
• W2017805604 creator A5035038202 @default.
• W2017805604 creator A5046857875 @default.
• W2017805604 creator A5055977594 @default.
• W2017805604 creator A5070752127 @default.
• W2017805604 creator A5072108506 @default.
• W2017805604 creator A5072208578 @default.
• W2017805604 creator A5089837595 @default.
• W2017805604 date "2000-06-01" @default.
• W2017805604 modified "2023-09-23" @default.
• W2017805604 title "Monitoring of minimal residual disease in patients with <i>MLL-AF6</i> -positive acute myeloid leukaemia by reverse transcriptase polymerase chain reaction" @default.
• W2017805604 cites W12190030 @default.
• W2017805604 cites W1512146889 @default.
• W2017805604 cites W1523721162 @default.
• W2017805604 cites W1591796471 @default.
• W2017805604 cites W1608878503 @default.
• W2017805604 cites W1973454171 @default.
• W2017805604 cites W1976439451 @default.
• W2017805604 cites W1976631985 @default.
• W2017805604 cites W1978762586 @default.
• W2017805604 cites W1979969603 @default.
• W2017805604 cites W1982640053 @default.
• W2017805604 cites W2004367648 @default.
• W2017805604 cites W2028295142 @default.
• W2017805604 cites W2044884259 @default.
• W2017805604 cites W2044937012 @default.
• W2017805604 cites W2046414425 @default.
• W2017805604 cites W2047480444 @default.
• W2017805604 cites W2070044750 @default.
• W2017805604 cites W2079604568 @default.
• W2017805604 cites W2091260442 @default.
• W2017805604 cites W2095184701 @default.
• W2017805604 cites W2112087352 @default.
• W2017805604 cites W2126800428 @default.
• W2017805604 cites W2150253932 @default.
• W2017805604 cites W2225510644 @default.
• W2017805604 cites W2318674152 @default.
• W2017805604 cites W2331467540 @default.
• W2017805604 cites W4230006048 @default.
• W2017805604 cites W74111399 @default.
• W2017805604 doi "https://doi.org/10.1046/j.1365-2141.2000.02076.x" @default.
• W2017805604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10886213" @default.
• W2017805604 hasPublicationYear "2000" @default.
• W2017805604 type Work @default.
• W2017805604 sameAs 2017805604 @default.
• W2017805604 citedByCount "33" @default.
• W2017805604 countsByYear W20178056042013 @default.
• W2017805604 countsByYear W20178056042014 @default.
• W2017805604 countsByYear W20178056042015 @default.
• W2017805604 countsByYear W20178056042017 @default.
• W2017805604 countsByYear W20178056042020 @default.
• W2017805604 countsByYear W20178056042021 @default.
• W2017805604 crossrefType "journal-article" @default.
• W2017805604 hasAuthorship W2017805604A5020002610 @default.
• W2017805604 hasAuthorship W2017805604A5033965282 @default.
• W2017805604 hasAuthorship W2017805604A5034222353 @default.
• W2017805604 hasAuthorship W2017805604A5035038202 @default.
• W2017805604 hasAuthorship W2017805604A5046857875 @default.
• W2017805604 hasAuthorship W2017805604A5055977594 @default.
• W2017805604 hasAuthorship W2017805604A5070752127 @default.
• W2017805604 hasAuthorship W2017805604A5072108506 @default.
• W2017805604 hasAuthorship W2017805604A5072208578 @default.
• W2017805604 hasAuthorship W2017805604A5089837595 @default.
• W2017805604 hasConcept C104317684 @default.
• W2017805604 hasConcept C126322002 @default.
• W2017805604 hasConcept C156719811 @default.
• W2017805604 hasConcept C2779823535 @default.
• W2017805604 hasConcept C2780007613 @default.
• W2017805604 hasConcept C36823959 @default.
• W2017805604 hasConcept C49105822 @default.
• W2017805604 hasConcept C54355233 @default.
• W2017805604 hasConcept C71924100 @default.
• W2017805604 hasConcept C86803240 @default.
• W2017805604 hasConcept C90924648 @default.
• W2017805604 hasConceptScore W2017805604C104317684 @default.
• W2017805604 hasConceptScore W2017805604C126322002 @default.
• W2017805604 hasConceptScore W2017805604C156719811 @default.
• W2017805604 hasConceptScore W2017805604C2779823535 @default.
• W2017805604 hasConceptScore W2017805604C2780007613 @default.
• W2017805604 hasConceptScore W2017805604C36823959 @default.
• W2017805604 hasConceptScore W2017805604C49105822 @default.
• W2017805604 hasConceptScore W2017805604C54355233 @default.
• W2017805604 hasConceptScore W2017805604C71924100 @default.
• W2017805604 hasConceptScore W2017805604C86803240 @default.
• W2017805604 hasConceptScore W2017805604C90924648 @default.
• W2017805604 hasIssue "3" @default.
• W2017805604 hasLocation W20178056041 @default.
• W2017805604 hasLocation W20178056042 @default.
• W2017805604 hasOpenAccess W2017805604 @default.
• W2017805604 hasPrimaryLocation W20178056041 @default.
• W2017805604 hasRelatedWork W1969475579 @default.
• W2017805604 hasRelatedWork W2010546152 @default.
• W2017805604 hasRelatedWork W2014506455 @default.
• W2017805604 hasRelatedWork W2099866477 @default.

• next