Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017805812> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2017805812 endingPage "1622" @default.
- W2017805812 startingPage "1615" @default.
- W2017805812 abstract "A high frequency of clonal precursor B cells producing lytic antibodies to syngeneic erythrocytes treated with bromelain (BMRC) is revealed in normal mouse spleen cells by lipopolysaccharide-driven limiting dilution analysis. All such specificities are recovered as activated blasts after density gradient fractionation, the “small lymphocyte” pool being depleted of anti-BMRC reactivities. In contrast, the spleens of athymic (nude) mice contain undetectably low frequencies of these specificities in either lymphocyte compartment. Transfer of relatively low numbers of normal syngeneic splenic T lymphocytes to adult nude mice restores the high frequency of anti-BMRC clonal precursor B cells, again in the activated, but not in the resting spleen cell fractions. Large total T cells are more than tenfold better than resting T cells in reconstitution potential, as are enriched CD4+ as compared to CD8+ cells which are practically devoid of activity in this respect. These results apply exclusively to B cells at a differentiative stage that allows for extensive clonal expansion, since there is a marked difference between the frequency of clonal precursors determined by limiting dilution analysis and the frequency of Ig-secreting plaque-forming cells of the same specificity, and induced by the same mitogen in short-term cultures. The implications of these findings for the physiology of autoreactivity and repertoire selection in the compartment of perinatal B cells are discussed." @default.
- W2017805812 created "2016-06-24" @default.
- W2017805812 creator A5058729669 @default.
- W2017805812 creator A5063516235 @default.
- W2017805812 creator A5071049246 @default.
- W2017805812 creator A5086999065 @default.
- W2017805812 creator A5091040882 @default.
- W2017805812 date "1988-10-01" @default.
- W2017805812 modified "2023-10-14" @default.
- W2017805812 title "T cell dependence of the “natural” autoreactive B cell activation in the spleen of normal mice" @default.
- W2017805812 cites W1965908356 @default.
- W2017805812 cites W1967587838 @default.
- W2017805812 cites W1974399445 @default.
- W2017805812 cites W1980420110 @default.
- W2017805812 cites W1981863728 @default.
- W2017805812 cites W1992301025 @default.
- W2017805812 cites W2001154029 @default.
- W2017805812 cites W2016190951 @default.
- W2017805812 cites W2031578446 @default.
- W2017805812 cites W2032626982 @default.
- W2017805812 cites W2035093315 @default.
- W2017805812 cites W2035413498 @default.
- W2017805812 cites W2045513702 @default.
- W2017805812 cites W2063359754 @default.
- W2017805812 cites W2070437307 @default.
- W2017805812 cites W2079769743 @default.
- W2017805812 cites W2080890675 @default.
- W2017805812 cites W2084093106 @default.
- W2017805812 cites W2094583086 @default.
- W2017805812 cites W2095433810 @default.
- W2017805812 cites W2137840076 @default.
- W2017805812 cites W2146663950 @default.
- W2017805812 cites W2152088959 @default.
- W2017805812 cites W2155013910 @default.
- W2017805812 cites W2159562836 @default.
- W2017805812 cites W2169535002 @default.
- W2017805812 doi "https://doi.org/10.1002/eji.1830181022" @default.
- W2017805812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3263923" @default.
- W2017805812 hasPublicationYear "1988" @default.
- W2017805812 type Work @default.
- W2017805812 sameAs 2017805812 @default.
- W2017805812 citedByCount "54" @default.
- W2017805812 countsByYear W20178058122014 @default.
- W2017805812 crossrefType "journal-article" @default.
- W2017805812 hasAuthorship W2017805812A5058729669 @default.
- W2017805812 hasAuthorship W2017805812A5063516235 @default.
- W2017805812 hasAuthorship W2017805812A5071049246 @default.
- W2017805812 hasAuthorship W2017805812A5086999065 @default.
- W2017805812 hasAuthorship W2017805812A5091040882 @default.
- W2017805812 hasConcept C1491633281 @default.
- W2017805812 hasConcept C153911025 @default.
- W2017805812 hasConcept C159654299 @default.
- W2017805812 hasConcept C167672396 @default.
- W2017805812 hasConcept C182615771 @default.
- W2017805812 hasConcept C203014093 @default.
- W2017805812 hasConcept C2522874641 @default.
- W2017805812 hasConcept C2777761686 @default.
- W2017805812 hasConcept C2778453870 @default.
- W2017805812 hasConcept C2780931953 @default.
- W2017805812 hasConcept C55493867 @default.
- W2017805812 hasConcept C86803240 @default.
- W2017805812 hasConcept C8891405 @default.
- W2017805812 hasConcept C95444343 @default.
- W2017805812 hasConceptScore W2017805812C1491633281 @default.
- W2017805812 hasConceptScore W2017805812C153911025 @default.
- W2017805812 hasConceptScore W2017805812C159654299 @default.
- W2017805812 hasConceptScore W2017805812C167672396 @default.
- W2017805812 hasConceptScore W2017805812C182615771 @default.
- W2017805812 hasConceptScore W2017805812C203014093 @default.
- W2017805812 hasConceptScore W2017805812C2522874641 @default.
- W2017805812 hasConceptScore W2017805812C2777761686 @default.
- W2017805812 hasConceptScore W2017805812C2778453870 @default.
- W2017805812 hasConceptScore W2017805812C2780931953 @default.
- W2017805812 hasConceptScore W2017805812C55493867 @default.
- W2017805812 hasConceptScore W2017805812C86803240 @default.
- W2017805812 hasConceptScore W2017805812C8891405 @default.
- W2017805812 hasConceptScore W2017805812C95444343 @default.
- W2017805812 hasIssue "10" @default.
- W2017805812 hasLocation W20178058121 @default.
- W2017805812 hasLocation W20178058122 @default.
- W2017805812 hasOpenAccess W2017805812 @default.
- W2017805812 hasPrimaryLocation W20178058121 @default.
- W2017805812 hasRelatedWork W1575939438 @default.
- W2017805812 hasRelatedWork W1598727318 @default.
- W2017805812 hasRelatedWork W2009030613 @default.
- W2017805812 hasRelatedWork W2015897818 @default.
- W2017805812 hasRelatedWork W2023330742 @default.
- W2017805812 hasRelatedWork W2090531156 @default.
- W2017805812 hasRelatedWork W2158252191 @default.
- W2017805812 hasRelatedWork W2398158390 @default.
- W2017805812 hasRelatedWork W2410188864 @default.
- W2017805812 hasRelatedWork W4238636496 @default.
- W2017805812 hasVolume "18" @default.
- W2017805812 isParatext "false" @default.
- W2017805812 isRetracted "false" @default.
- W2017805812 magId "2017805812" @default.
- W2017805812 workType "article" @default.