FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017806432> ?p ?o ?g. }

• W2017806432 endingPage "69" @default.
• W2017806432 startingPage "60" @default.
• W2017806432 abstract "Although there is considerable evidence that patients with schizophrenia fail to activate the dorsolateral prefrontal cortex (DLPFC) to the degree seen in normal comparison subjects when performing working memory or executive tasks, hypofrontality may be coupled with relatively increased activity in other brain regions. However, most imaging studies of working memory in schizophrenia have focused on DLPFC activity. The goal of this work is to review functional neuroimaging studies that contrasted patients with schizophrenia and healthy comparison subjects during a prototypical working memory task, the n-back paradigm, to highlight areas of hyper- and hypoactivation in schizophrenia. We utilize a quantitative meta-analysis method to review 12 imaging studies where patients with schizophrenia were contrasted with healthy comparison subjects while performing the n-back paradigm. Although we find clear support for hypofrontality, we also document consistently increased activation in anterior cingulate and left frontal pole regions in patients with schizophrenia compared to that in controls. These data suggest that whereas reduced DLPFC activation is reported consistently in patients with schizophrenia relative to healthy subjects, abnormal activation patterns are not restricted to this region, raising questions as to whether the pathophysiological dysfunction in schizophrenia is specific to the DLPFC and about the relationship between impaired performance and aberrant activation patterns. The complex pattern of hyper- and hypoactivation consistently found across studies implies that rather than focusing on DLPFC dysregulation, researchers should consider the entire network of regions involved in a given task when making inferences about the biological mechanisms of schizophrenia." @default.
• W2017806432 created "2016-06-24" @default.
• W2017806432 creator A5012270886 @default.
• W2017806432 creator A5047405979 @default.
• W2017806432 creator A5050499772 @default.
• W2017806432 creator A5055616629 @default.
• W2017806432 creator A5067571294 @default.
• W2017806432 creator A5074299304 @default.
• W2017806432 creator A5087036321 @default.
• W2017806432 date "2005-01-01" @default.
• W2017806432 modified "2023-10-03" @default.
• W2017806432 title "Beyond hypofrontality: A quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia" @default.
• W2017806432 cites W107261713 @default.
• W2017806432 cites W144271823 @default.
• W2017806432 cites W1509285273 @default.
• W2017806432 cites W1530683550 @default.
• W2017806432 cites W162660928 @default.
• W2017806432 cites W1963754370 @default.
• W2017806432 cites W1970167327 @default.
• W2017806432 cites W1971254674 @default.
• W2017806432 cites W1972952278 @default.
• W2017806432 cites W1977410909 @default.
• W2017806432 cites W1979773754 @default.
• W2017806432 cites W1983366569 @default.
• W2017806432 cites W1994517931 @default.
• W2017806432 cites W2000697043 @default.
• W2017806432 cites W2006883575 @default.
• W2017806432 cites W2008591007 @default.
• W2017806432 cites W2008963708 @default.
• W2017806432 cites W2010230693 @default.
• W2017806432 cites W2010974198 @default.
• W2017806432 cites W2016444985 @default.
• W2017806432 cites W2019351781 @default.
• W2017806432 cites W2021620877 @default.
• W2017806432 cites W2021687531 @default.
• W2017806432 cites W2025260177 @default.
• W2017806432 cites W2029059267 @default.
• W2017806432 cites W2036866940 @default.
• W2017806432 cites W2037936690 @default.
• W2017806432 cites W2040910278 @default.
• W2017806432 cites W2043941998 @default.
• W2017806432 cites W2055091900 @default.
• W2017806432 cites W2060259639 @default.
• W2017806432 cites W2065406573 @default.
• W2017806432 cites W2076801804 @default.
• W2017806432 cites W2078430761 @default.
• W2017806432 cites W2078438409 @default.
• W2017806432 cites W2080880668 @default.
• W2017806432 cites W2084760609 @default.
• W2017806432 cites W2087866447 @default.
• W2017806432 cites W2089649622 @default.
• W2017806432 cites W2090873199 @default.
• W2017806432 cites W2099935324 @default.
• W2017806432 cites W2100821684 @default.
• W2017806432 cites W2104527583 @default.
• W2017806432 cites W2106646290 @default.
• W2017806432 cites W2114931946 @default.
• W2017806432 cites W2122657028 @default.
• W2017806432 cites W2123510839 @default.
• W2017806432 cites W2124470632 @default.
• W2017806432 cites W2127587466 @default.
• W2017806432 cites W2133510276 @default.
• W2017806432 cites W2137162843 @default.
• W2017806432 cites W2138022605 @default.
• W2017806432 cites W2140255740 @default.
• W2017806432 cites W2148601705 @default.
• W2017806432 cites W2149983435 @default.
• W2017806432 cites W2151308847 @default.
• W2017806432 cites W2151505978 @default.
• W2017806432 cites W2152928279 @default.
• W2017806432 cites W2153525031 @default.
• W2017806432 cites W2154540835 @default.
• W2017806432 cites W2155125375 @default.
• W2017806432 cites W2159006998 @default.
• W2017806432 cites W2159927205 @default.
• W2017806432 cites W2163274894 @default.
• W2017806432 cites W2165389751 @default.
• W2017806432 cites W2166560562 @default.
• W2017806432 cites W2169598865 @default.
• W2017806432 cites W2207884955 @default.
• W2017806432 cites W2207914931 @default.
• W2017806432 cites W2468686792 @default.
• W2017806432 cites W2892330318 @default.
• W2017806432 cites W4247080121 @default.
• W2017806432 cites W4255380808 @default.
• W2017806432 cites W4376453205 @default.
• W2017806432 cites W83166814 @default.
• W2017806432 doi "https://doi.org/10.1002/hbm.20138" @default.
• W2017806432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6871703" @default.
• W2017806432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15846819" @default.
• W2017806432 hasPublicationYear "2005" @default.
• W2017806432 type Work @default.
• W2017806432 sameAs 2017806432 @default.
• W2017806432 citedByCount "564" @default.
• W2017806432 countsByYear W20178064322012 @default.
• W2017806432 countsByYear W20178064322013 @default.
• W2017806432 countsByYear W20178064322014 @default.
• W2017806432 countsByYear W20178064322015 @default.

• next