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- W2017806462 abstract "Retinoic acid induces differentiation of preosteoblastic cells. We have demonstrated that osteoblastic differentiation and down-regulation of transforming growth factor (TGF)-β receptors requires the interaction of type I collagen with α2β1 integrin (J Biol Chem 271: 3938-3944, 1996). The purpose of this study was to clarify the role of collagen in retinoic acid-induced differentiation and down-regulation of TGF-β receptors using preosteoblastic RCT-1 cells. Retinoic acid enhanced the expression of alkaline phosphatase and type I collagen, and reduced TGF-β receptors in these cells. Inhibiting collagen synthesis abolished these changes. Because TGF-β inhibits osteoblastic differentiation, the changes described here may contribute to the osteoblastic differentiation by retinoic acid." @default.
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- W2017806462 date "1997-01-01" @default.
- W2017806462 modified "2023-10-04" @default.
- W2017806462 title "Role of Collagen in Retinoic Acid-induced Differentiation and Down-regulation of TGF-.BETA. Receptors in Rat Preosteoblastic RCT-1 Cells." @default.
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- W2017806462 doi "https://doi.org/10.1507/endocrj.44.375" @default.
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