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• W2017809128 abstract "While the error theory of ageing has attracted significant interest in recent times and was widely debated, in most cases the experimental tests and results (in favour or against it) were relevant only for consideration of Orgel's “error catastrophe” theory, which relates the possible mechanism of cellular ageing with self-propagation of errors in translational systems. However, Orgel's idea was one of several different “error theories”, some translational and some more general. The more comprehensive theory of errors in the synthesis of macromolecules as the cause of ageing developed earlier than the “error catastrophe” explanation, and considered the infidelity of synthesis of DNA, RNAs and proteins as closely interconnected. It also considered the level of errors in protein synthesis as a balance between error-inducing and error-repairing factors and did not expect the “error catastrophe” as inevitable. The usual level of random errors of synthesis could be rather low or slowly increasing during cellular ageing, but mostly the irreversible changes of cellular structures at the functional level, which appear under the influence of errors of protein synthesis, transcription and reproduction of DNA and some other deteriorative factors, are more evident accumulators of age changes. The attempt to update this theory made in this review shows that the age-relevant changes of proteins are also much more complex than just the errors of those active in translation. Ageing at the protein level depends on the types of protein, their “half-life”, structural role, origin of error, post-translational changes, etc. Some proteins are more “change-prone” than others and no simple test to prove or to invalidate the error theory is feasible." @default.
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• W2017809128 title "The role of infidelity of transfer of information for the accumulation of age changes in differentiated cells" @default.
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• W2017809128 doi "https://doi.org/10.1016/0047-6374(80)90102-5" @default.
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