FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017809266> ?p ?o ?g. }

• W2017809266 endingPage "140" @default.
• W2017809266 startingPage "132" @default.
• W2017809266 abstract "Abstract— Bis(di-isobutyl octadecylsiloxy)silicon 2,3-naphthalocy-anine (isoBOSINC) is a representative of a group of naphthalocyanine derivatives with spectral and photophysical properties that make them attractive candidates for photodynamic therapy (PDT). Tissue distributions were studied in tumor-bearing rats as a function of delivery system and time following administration. The tumor model was an N-(4-[5-nitro-2-furyl]-2-thiazolyl) formamide (FANFT)-induced urothelial cell carcinoma transplanted into one hind leg of male Fischer 344 rats; isoBOSINC was delivered to the rats by intravenous injection of 0.50 mg/kg of body weight as a suspension either in 10% Tween 80 in saline (Tween) or 10% (Cremophor® EL + propylene glycol) in saline (Cremophor). The isoBOSINC was isolated from several tissues and organs, as well as tumors and peritumoral muscles and skin. Quantitation was by a high-performance liquid chromatographic technique with detection that utilizes the native fluorescence of the naphthalocyanine derivative. Independent of the delivery system, the dye was retained in tumors at higher concentrations than in normal tissues, except for spleen and liver. The isoBOSINC retention in tumors was high and was vehicle dependent. For Tween, the maximal ratio of dye in tumor versus peritumoral muscle occurred 12 h after injection; for Cremophor, the maximal ratio occurred later, 336 h postinjection. When the drug was delivered in Tween, isoBOSINC in serum showed two compartment kinetics: half-lives of about 2 and 11 h were found for the distribution and the elimination phases, respectively. When Cremophor was the vehicle, the elimination half-life was about 20 h, and one compartment kinetics was observed. The latter findings may explain the generally higher levels of the dye attained by the tissues at later times with Cremophor as the vehicle. An interesting exception wasthat after 7 and 14 days postinjection in Tween, the levels of dye found in testes were six- to seven-fold higher than those found after Cremophor delivery. Levels of dye were very low or not detectable in the brain. Optimal parameters for PDT of tumors with this novel photosensitizer are clearly time- and vehicle-dependent, and future PDT studies will need to incorporate these modulators." @default.
• W2017809266 created "2016-06-24" @default.
• W2017809266 creator A5009626835 @default.
• W2017809266 creator A5011048863 @default.
• W2017809266 creator A5017934215 @default.
• W2017809266 creator A5029953722 @default.
• W2017809266 creator A5081087791 @default.
• W2017809266 date "1996-01-01" @default.
• W2017809266 modified "2023-10-15" @default.
• W2017809266 title "Effect of Delivery System on the Pharmacokinetics and Tissue Distribution of bis(Di-lsobutyl Octadecylsiloxy)Silicon 2,3-Naphthalocyanine (isoBOSINC), a Photosensitizer for Tumor Therapy" @default.
• W2017809266 cites W1966935668 @default.
• W2017809266 cites W1973718760 @default.
• W2017809266 cites W1978703040 @default.
• W2017809266 cites W1987046265 @default.
• W2017809266 cites W1992180725 @default.
• W2017809266 cites W1995323622 @default.
• W2017809266 cites W2001213580 @default.
• W2017809266 cites W2010681517 @default.
• W2017809266 cites W2013584484 @default.
• W2017809266 cites W2013719470 @default.
• W2017809266 cites W2023387050 @default.
• W2017809266 cites W2028224679 @default.
• W2017809266 cites W2035157707 @default.
• W2017809266 cites W2039553337 @default.
• W2017809266 cites W2041794357 @default.
• W2017809266 cites W2052870565 @default.
• W2017809266 cites W2054999083 @default.
• W2017809266 cites W2061420085 @default.
• W2017809266 cites W2071386813 @default.
• W2017809266 cites W2073859633 @default.
• W2017809266 cites W2139857302 @default.
• W2017809266 cites W2145482294 @default.
• W2017809266 cites W2159465781 @default.
• W2017809266 cites W2401509163 @default.
• W2017809266 cites W2411390277 @default.
• W2017809266 cites W2413239466 @default.
• W2017809266 cites W2425248381 @default.
• W2017809266 cites W2950704792 @default.
• W2017809266 cites W4246832840 @default.
• W2017809266 doi "https://doi.org/10.1111/j.1751-1097.1996.tb03004.x" @default.
• W2017809266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8577866" @default.
• W2017809266 hasPublicationYear "1996" @default.
• W2017809266 type Work @default.
• W2017809266 sameAs 2017809266 @default.
• W2017809266 citedByCount "14" @default.
• W2017809266 countsByYear W20178092662018 @default.
• W2017809266 countsByYear W20178092662019 @default.
• W2017809266 countsByYear W20178092662020 @default.
• W2017809266 crossrefType "journal-article" @default.
• W2017809266 hasAuthorship W2017809266A5009626835 @default.
• W2017809266 hasAuthorship W2017809266A5011048863 @default.
• W2017809266 hasAuthorship W2017809266A5017934215 @default.
• W2017809266 hasAuthorship W2017809266A5029953722 @default.
• W2017809266 hasAuthorship W2017809266A5081087791 @default.
• W2017809266 hasConcept C110121322 @default.
• W2017809266 hasConcept C112705442 @default.
• W2017809266 hasConcept C126322002 @default.
• W2017809266 hasConcept C134018914 @default.
• W2017809266 hasConcept C134306372 @default.
• W2017809266 hasConcept C161790260 @default.
• W2017809266 hasConcept C178790620 @default.
• W2017809266 hasConcept C185592680 @default.
• W2017809266 hasConcept C2776964284 @default.
• W2017809266 hasConcept C2777397205 @default.
• W2017809266 hasConcept C2779191827 @default.
• W2017809266 hasConcept C2780931953 @default.
• W2017809266 hasConcept C2781323092 @default.
• W2017809266 hasConcept C2781469039 @default.
• W2017809266 hasConcept C33923547 @default.
• W2017809266 hasConcept C43617362 @default.
• W2017809266 hasConcept C55493867 @default.
• W2017809266 hasConcept C65165184 @default.
• W2017809266 hasConcept C71924100 @default.
• W2017809266 hasConcept C75473681 @default.
• W2017809266 hasConcept C98274493 @default.
• W2017809266 hasConceptScore W2017809266C110121322 @default.
• W2017809266 hasConceptScore W2017809266C112705442 @default.
• W2017809266 hasConceptScore W2017809266C126322002 @default.
• W2017809266 hasConceptScore W2017809266C134018914 @default.
• W2017809266 hasConceptScore W2017809266C134306372 @default.
• W2017809266 hasConceptScore W2017809266C161790260 @default.
• W2017809266 hasConceptScore W2017809266C178790620 @default.
• W2017809266 hasConceptScore W2017809266C185592680 @default.
• W2017809266 hasConceptScore W2017809266C2776964284 @default.
• W2017809266 hasConceptScore W2017809266C2777397205 @default.
• W2017809266 hasConceptScore W2017809266C2779191827 @default.
• W2017809266 hasConceptScore W2017809266C2780931953 @default.
• W2017809266 hasConceptScore W2017809266C2781323092 @default.
• W2017809266 hasConceptScore W2017809266C2781469039 @default.
• W2017809266 hasConceptScore W2017809266C33923547 @default.
• W2017809266 hasConceptScore W2017809266C43617362 @default.
• W2017809266 hasConceptScore W2017809266C55493867 @default.
• W2017809266 hasConceptScore W2017809266C65165184 @default.
• W2017809266 hasConceptScore W2017809266C71924100 @default.
• W2017809266 hasConceptScore W2017809266C75473681 @default.
• W2017809266 hasConceptScore W2017809266C98274493 @default.
• W2017809266 hasIssue "1" @default.
• W2017809266 hasLocation W20178092661 @default.

• next