Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017814429> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2017814429 endingPage "500" @default.
- W2017814429 startingPage "494" @default.
- W2017814429 abstract "The effect of several inhibitors on formation of 6-methylsalicylic acid (MSA) synthetase activity in two isolates of Penicillium patulum NRRL 2159A has been studied. Synthetase activity was measured in crude extracts by the incorporation of 14C-malonyl-CoA into MSA. The two isolates differ in the time of appearance of MSA synthetase after transfer from a germinating medium to Czapek-Dox medium. Cycloheximide at a concentration of 0.3 μg/ml stimulates the formation of synthetase activity in both strains, but inhibits formation of the activity at a concentration of 10 μg/ml. In comparing this effect with the inhibition of protein synthesis by cyclo-heximide, it was found that a concentration of 10 μg/ml is sufficient to block in vivo incorporation of leucine-14C into trichloroacetic acid-insoluble material, while 0.3 μg/ml only partially inhibits this incorporation. dl-p-Fluorophenylalanine and dl-4-methyltryptophan also stimulate formation of MSA synthetase activity at a concentration of 10–100 μg/ml and partially inhibit formation at 1 mg/ml. dl-5-Methyltryptophan shows slight inhibition but little stimulation. dl-Ethionine at 100μg/ml partially inhibits MSA synthetase appearance. It is suggested that the inhibitors produce metabolic changes similar to those found in older cultures when MSA synthesis is prevalent. The possibility of applying this stimulatory effect to increase production yields of some antibiotics is mentioned." @default.
- W2017814429 created "2016-06-24" @default.
- W2017814429 creator A5052680715 @default.
- W2017814429 date "1967-11-01" @default.
- W2017814429 modified "2023-09-28" @default.
- W2017814429 title "Effects of cycloheximide and amino acid analogues on biosynthesis of 6-methylsalicylic acid in Penicillium patulum" @default.
- W2017814429 cites W1042963012 @default.
- W2017814429 cites W1459976592 @default.
- W2017814429 cites W1480051637 @default.
- W2017814429 cites W1521878726 @default.
- W2017814429 cites W157931537 @default.
- W2017814429 cites W1979665960 @default.
- W2017814429 cites W1980224338 @default.
- W2017814429 cites W1993342200 @default.
- W2017814429 cites W2000578518 @default.
- W2017814429 cites W2033005336 @default.
- W2017814429 cites W2045180554 @default.
- W2017814429 cites W2072415579 @default.
- W2017814429 cites W2204335319 @default.
- W2017814429 cites W2241611704 @default.
- W2017814429 cites W2320934986 @default.
- W2017814429 cites W2328273641 @default.
- W2017814429 cites W2335914485 @default.
- W2017814429 doi "https://doi.org/10.1016/0003-9861(67)90224-x" @default.
- W2017814429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6066255" @default.
- W2017814429 hasPublicationYear "1967" @default.
- W2017814429 type Work @default.
- W2017814429 sameAs 2017814429 @default.
- W2017814429 citedByCount "18" @default.
- W2017814429 crossrefType "journal-article" @default.
- W2017814429 hasAuthorship W2017814429A5052680715 @default.
- W2017814429 hasConcept C181199279 @default.
- W2017814429 hasConcept C185592680 @default.
- W2017814429 hasConcept C2776580952 @default.
- W2017814429 hasConcept C2778128677 @default.
- W2017814429 hasConcept C2780486903 @default.
- W2017814429 hasConcept C2780912031 @default.
- W2017814429 hasConcept C3675279 @default.
- W2017814429 hasConcept C515207424 @default.
- W2017814429 hasConcept C553450214 @default.
- W2017814429 hasConcept C55493867 @default.
- W2017814429 hasConceptScore W2017814429C181199279 @default.
- W2017814429 hasConceptScore W2017814429C185592680 @default.
- W2017814429 hasConceptScore W2017814429C2776580952 @default.
- W2017814429 hasConceptScore W2017814429C2778128677 @default.
- W2017814429 hasConceptScore W2017814429C2780486903 @default.
- W2017814429 hasConceptScore W2017814429C2780912031 @default.
- W2017814429 hasConceptScore W2017814429C3675279 @default.
- W2017814429 hasConceptScore W2017814429C515207424 @default.
- W2017814429 hasConceptScore W2017814429C553450214 @default.
- W2017814429 hasConceptScore W2017814429C55493867 @default.
- W2017814429 hasIssue "2" @default.
- W2017814429 hasLocation W20178144291 @default.
- W2017814429 hasLocation W20178144292 @default.
- W2017814429 hasOpenAccess W2017814429 @default.
- W2017814429 hasPrimaryLocation W20178144291 @default.
- W2017814429 hasRelatedWork W118575299 @default.
- W2017814429 hasRelatedWork W1553509744 @default.
- W2017814429 hasRelatedWork W1780521428 @default.
- W2017814429 hasRelatedWork W1978161393 @default.
- W2017814429 hasRelatedWork W2000184187 @default.
- W2017814429 hasRelatedWork W2000886424 @default.
- W2017814429 hasRelatedWork W2021436685 @default.
- W2017814429 hasRelatedWork W2044628742 @default.
- W2017814429 hasRelatedWork W2091524209 @default.
- W2017814429 hasRelatedWork W2731175349 @default.
- W2017814429 hasVolume "122" @default.
- W2017814429 isParatext "false" @default.
- W2017814429 isRetracted "false" @default.
- W2017814429 magId "2017814429" @default.
- W2017814429 workType "article" @default.