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• W2017816448 abstract "The hippocampus is crucial for spatial memory formation, yet it does not store long-lasting memories. By combining functional brain imaging and region-specific neuronal inactivation in mice, we identified prefrontal and anterior cingulate cortices as critical for storage and retrieval of remote spatial memories [correction]. Imaging of activity-dependent genes also revealed an involvement of parietal and retrosplenial cortices during consolidation of remote memory. Long-term memory storage within some of these neocortical regions was accompanied by structural changes including synaptogenesis and laminar reorganization, concomitant with a functional disengagement of the hippocampus and posterior cingulate cortex [correction]. Thus, consolidation of spatial memory requires a time-dependent hippocampal-cortical dialogue, ultimately enabling widespread cortical networks to mediate effortful recall and use of cortically stored remote memories independently." @default.
• W2017816448 created "2016-06-24" @default.
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• W2017816448 date "2004-07-02" @default.
• W2017816448 modified "2023-10-17" @default.
• W2017816448 title "Sites of Neocortical Reorganization Critical for Remote Spatial Memory" @default.
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• W2017816448 doi "https://doi.org/10.1126/science.1098180" @default.
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