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- W2017819783 abstract "The gold(I)-catalyzed cycloisomerization of 1,5-enynes and 1,4-allylallenes to tetracyclododecane and tetracyclotridecane derivatives, respectively, is reported. Complexation of the cationic gold(I) complex to either the alkyne or allene moiety induces an intramolecular addition of the alkene, leading to a gold(I)-stabilized carbenoid intermediate. This intermediate undergoes a formal sp3 C−H insertion to generate the tetracyclic adduct. A series of deuterium labeling experiments showed that the C−H functionalization step proceeds with an inverse kinetic isotope effect." @default.
- W2017819783 created "2016-06-24" @default.
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- W2017819783 date "2009-02-10" @default.
- W2017819783 modified "2023-10-07" @default.
- W2017819783 title "Au(I)-Catalyzed Cycloisomerizations Terminated by sp<sup>3</sup> C−H Bond Insertion" @default.
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- W2017819783 doi "https://doi.org/10.1021/ja808780r" @default.
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