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• W2017821732 abstract "We evaluated the role of IP3 in sugar taste reception in Drosophila melanogaster by inactivating the IP3 signaling using genetic tools. We used the “IP3 sponge,” composed of the modified ligand-binding domain from the mouse IP3 receptor, which was designed to absorb IP3 in competition with native IP3 receptors. Another tool was a transgene that generates double-stranded RNA against IP3 receptor mRNA. Both inhibitors diminished the sensitivity of flies to trehalose and sucrose, as estimated by behavioral assays and electrophysiological recordings from the sugar receptor cells. The result indicates that IP3 signaling is indispensable for sugar reception in Drosophila." @default.
• W2017821732 created "2016-06-24" @default.
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• W2017821732 date "2005-01-01" @default.
• W2017821732 modified "2023-10-03" @default.
• W2017821732 title "TARGETED EXPRESSION OF IP₃SPONGE AND IP₃<scp>DS</scp>RNA IMPAIRES SUGAR TASTE SENSATION IN<i>DROSOPHILA</i>" @default.
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• W2017821732 doi "https://doi.org/10.1080/01677060600569713" @default.
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