Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017822016> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2017822016 endingPage "510" @default.
- W2017822016 startingPage "501" @default.
- W2017822016 abstract "Genes involved in all aspects of tumor development and growth can become aberrantly methylated in tumor cells, including genes involved in apoptosis and cell cycle regulation. Decitabine, 2´-deoxy-5-azacytidine, can inhibit DNA methyltransferases and reverse epigenetic silencing of aberrantly methylated genes. Nucleoside DNA methyltransferase inhibitors, such as decitabine, have been reported to have antitumor activity, especially against hematologic malignancies. Such demethylating agents have been proposed to reactivate tumor suppressor genes aberrantly methylated in tumor cells, leading to inhibition of tumor growth. An important consequence of this is that, unlike conventional cytotoxic agents, it may be best to use such drugs at concentrations lower than the maximum tolerated dose and in a manner dependent on their demethylating activity. Furthermore, synergistic activity with other types of investigational epigenetic therapies and existing chemotherapies opens the possibility of rational combinations and scheduling of these agents based on their biologic activity." @default.
- W2017822016 created "2016-06-24" @default.
- W2017822016 creator A5004328721 @default.
- W2017822016 creator A5053758493 @default.
- W2017822016 date "2004-08-01" @default.
- W2017822016 modified "2023-09-23" @default.
- W2017822016 title "Demethylation of DNA by decitabine in cancer chemotherapy" @default.
- W2017822016 cites W1972933434 @default.
- W2017822016 cites W1992274074 @default.
- W2017822016 cites W2007042448 @default.
- W2017822016 cites W2025213305 @default.
- W2017822016 cites W2046509449 @default.
- W2017822016 cites W2083535257 @default.
- W2017822016 cites W2091658754 @default.
- W2017822016 cites W2137546188 @default.
- W2017822016 cites W2150162153 @default.
- W2017822016 cites W2151836161 @default.
- W2017822016 cites W253251876 @default.
- W2017822016 cites W4233749076 @default.
- W2017822016 doi "https://doi.org/10.1586/14737140.4.4.501" @default.
- W2017822016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15270655" @default.
- W2017822016 hasPublicationYear "2004" @default.
- W2017822016 type Work @default.
- W2017822016 sameAs 2017822016 @default.
- W2017822016 citedByCount "39" @default.
- W2017822016 countsByYear W20178220162012 @default.
- W2017822016 countsByYear W20178220162013 @default.
- W2017822016 countsByYear W20178220162014 @default.
- W2017822016 countsByYear W20178220162015 @default.
- W2017822016 countsByYear W20178220162016 @default.
- W2017822016 countsByYear W20178220162017 @default.
- W2017822016 countsByYear W20178220162018 @default.
- W2017822016 countsByYear W20178220162019 @default.
- W2017822016 countsByYear W20178220162021 @default.
- W2017822016 countsByYear W20178220162022 @default.
- W2017822016 crossrefType "journal-article" @default.
- W2017822016 hasAuthorship W2017822016A5004328721 @default.
- W2017822016 hasAuthorship W2017822016A5053758493 @default.
- W2017822016 hasConcept C104317684 @default.
- W2017822016 hasConcept C121608353 @default.
- W2017822016 hasConcept C126322002 @default.
- W2017822016 hasConcept C150194340 @default.
- W2017822016 hasConcept C190727270 @default.
- W2017822016 hasConcept C2776239401 @default.
- W2017822016 hasConcept C2780235182 @default.
- W2017822016 hasConcept C2780737395 @default.
- W2017822016 hasConcept C33288867 @default.
- W2017822016 hasConcept C41091548 @default.
- W2017822016 hasConcept C502942594 @default.
- W2017822016 hasConcept C54355233 @default.
- W2017822016 hasConcept C71924100 @default.
- W2017822016 hasConcept C86803240 @default.
- W2017822016 hasConcept C91965660 @default.
- W2017822016 hasConcept C98274493 @default.
- W2017822016 hasConceptScore W2017822016C104317684 @default.
- W2017822016 hasConceptScore W2017822016C121608353 @default.
- W2017822016 hasConceptScore W2017822016C126322002 @default.
- W2017822016 hasConceptScore W2017822016C150194340 @default.
- W2017822016 hasConceptScore W2017822016C190727270 @default.
- W2017822016 hasConceptScore W2017822016C2776239401 @default.
- W2017822016 hasConceptScore W2017822016C2780235182 @default.
- W2017822016 hasConceptScore W2017822016C2780737395 @default.
- W2017822016 hasConceptScore W2017822016C33288867 @default.
- W2017822016 hasConceptScore W2017822016C41091548 @default.
- W2017822016 hasConceptScore W2017822016C502942594 @default.
- W2017822016 hasConceptScore W2017822016C54355233 @default.
- W2017822016 hasConceptScore W2017822016C71924100 @default.
- W2017822016 hasConceptScore W2017822016C86803240 @default.
- W2017822016 hasConceptScore W2017822016C91965660 @default.
- W2017822016 hasConceptScore W2017822016C98274493 @default.
- W2017822016 hasIssue "4" @default.
- W2017822016 hasLocation W20178220161 @default.
- W2017822016 hasLocation W20178220162 @default.
- W2017822016 hasOpenAccess W2017822016 @default.
- W2017822016 hasPrimaryLocation W20178220161 @default.
- W2017822016 hasRelatedWork W2014904426 @default.
- W2017822016 hasRelatedWork W2104076485 @default.
- W2017822016 hasRelatedWork W2116269315 @default.
- W2017822016 hasRelatedWork W2133117955 @default.
- W2017822016 hasRelatedWork W2144504798 @default.
- W2017822016 hasRelatedWork W2168473428 @default.
- W2017822016 hasRelatedWork W2399755523 @default.
- W2017822016 hasRelatedWork W2400187771 @default.
- W2017822016 hasRelatedWork W2944780474 @default.
- W2017822016 hasRelatedWork W3031091294 @default.
- W2017822016 hasVolume "4" @default.
- W2017822016 isParatext "false" @default.
- W2017822016 isRetracted "false" @default.
- W2017822016 magId "2017822016" @default.
- W2017822016 workType "article" @default.