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• W2017823783 abstract "Here, we report the evolution of two star-shaped (five-way junction) deoxyribozymes from a catalytic DNA containing a three-way junction scaffold. The transition was shown to be a switch rather than a gradual progression. The star-shaped motifs, surprisingly, only took five selection cycles to be detected, and another four to dominate the evolving population. Chemical probing experiments indicated that the two deoxyribozymes belong to the same family despite noticeable variations in both the primary sequence and the secondary structure. Our findings not only describe the evolution of high-branching nucleic acid structures from a low-branching catalytic module, but they also illustrate the idea of deriving a rare structural motif by sampling the sequence variants of a given functional nucleic acid." @default.
• W2017823783 created "2016-06-24" @default.
• W2017823783 creator A5039579810 @default.
• W2017823783 creator A5081367802 @default.
• W2017823783 date "2006-10-01" @default.
• W2017823783 modified "2023-10-15" @default.
• W2017823783 title "Evolution of High-Branching Deoxyribozymes from a Catalytic DNA with a Three-Way Junction" @default.
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• W2017823783 doi "https://doi.org/10.1016/j.chembiol.2006.08.009" @default.
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