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- W2017830658 abstract "Background: The aim of this investigation was to assess clinical predictors of the glycosylated hemoglobin (HbA1C) response after the addition of a thiazolidinedione (TZD) to a biguanide, a sulfonylurea, or both in subjects with type 2 diabetes. Methods: Chart review (n = 68 physicians) was used to identify consecutive subjects started on a TZD. Qualifying subjects had been treated with pioglitazone (≥4 mg/day) or rosiglitazone (≥30 mg/day) for ≥12 weeks. Clinical characteristics and HbA1C responses were assessed for the purpose of creating an initial predictive response model (Study 1). A separate sample from a managed care database was used to independently validate the model (Study 2). Results: Data were collected from 4085 subjects (1365 in Study 1; 2720 in Study 2). In Study 1, baseline HbA1C was 8.2 ± 0.1%. Forty-five percent (611 of 1365) and 55% (754 of 1365) were prescribed pioglitazone and rosiglitazone, respectively. In multivariate regression, baseline HbA1C (β = −0.693%), age (β = −0.006%), and use of multiple agents at baseline (referent = single agent, β = 0.189%) were significant (P < 0.05) predictors, explaining 49% of the variance in HbA1C response in Study 1 and 44% of the variance in HbA1C response in the Study 2 sample. The model showed no material evidence of bias across the range of baseline HbA1C values. Conclusions: These results suggest that readily available clinical information, particularly baseline HbA1C, explains a substantial proportion of the variance in the response to TZD therapy." @default.
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- W2017830658 date "2007-12-01" @default.
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- W2017830658 title "Clinical Predictors of Glycosylated Hemoglobin Response to Thiazolidinedione Therapy" @default.
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- W2017830658 doi "https://doi.org/10.1089/dia.2007.0248" @default.
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