FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017831452> ?p ?o ?g. }

• W2017831452 endingPage "456" @default.
• W2017831452 startingPage "448" @default.
• W2017831452 abstract "Scopolamine produces rapid and significant symptom improvement in patients with depression, and most notably in patients who do not respond to current antidepressant treatments. Scopolamine is a nonselective muscarinic acetylcholine receptor antagonist, and it is not known which one or more of the five receptor subtypes in the muscarinic family are mediating these therapeutic effects. We used the mouse forced-swim test, an antidepressant detecting assay, in wild-type and transgenic mice in which each muscarinic receptor subtype had been genetically deleted to define the relevant receptor subtypes. Only the M₁ and M₂ knockout (KO) mice had a blunted response to scopolamine in the forced-swim assay. In contrast, the effects of the tricyclic antidepressant imipramine were not significantly altered by gene deletion of any of the five muscarinic receptors. The muscarinic antagonists biperiden, pirenzepine, and VU0255035 (<i>N</i>-[3-oxo-3-[4-(4-pyridinyl)-1-piper azinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide) with selectivity for M₁ over M₂ receptors also demonstrated activity in the forced-swim test, which was attenuated in M₁ but not M₂ receptor KO mice. An antagonist with selectivity of M₂ over M₁ receptors (SCH226206 [(2-amino-3-methyl-phenyl)-[4-[4-[[4-(3 chlorophenyl)sulfonylphenyl]methyl]-1-piperidyl]-1-piperidyl]methanone]) was also active in the forced-swim assay, and the effects were deleted in M₂^−/− mice. Brain exposure and locomotor activity in the KO mice demonstrated that these behavioral effects of scopolamine are pharmacodynamic in nature. These data establish muscarinic M₁ and M₂ receptors as sufficient to generate behavioral effects consistent with an antidepressant phenotype and therefore as potential targets in the antidepressant effects of scopolamine." @default.
• W2017831452 created "2016-06-24" @default.
• W2017831452 creator A5000414432 @default.
• W2017831452 creator A5013032842 @default.
• W2017831452 creator A5015871920 @default.
• W2017831452 creator A5022761123 @default.
• W2017831452 creator A5033607802 @default.
• W2017831452 creator A5043781065 @default.
• W2017831452 creator A5047992426 @default.
• W2017831452 creator A5052240068 @default.
• W2017831452 creator A5057928180 @default.
• W2017831452 creator A5079738340 @default.
• W2017831452 creator A5082607061 @default.
• W2017831452 creator A5084905250 @default.
• W2017831452 creator A5090899159 @default.
• W2017831452 date "2014-09-03" @default.
• W2017831452 modified "2023-09-27" @default.
• W2017831452 title "M₁and M₂Muscarinic Receptor Subtypes Regulate Antidepressant-Like Effects of the Rapidly Acting Antidepressant Scopolamine" @default.
• W2017831452 cites W1532134440 @default.
• W2017831452 cites W1610158505 @default.
• W2017831452 cites W1966676904 @default.
• W2017831452 cites W1969212890 @default.
• W2017831452 cites W1978745809 @default.
• W2017831452 cites W1979153848 @default.
• W2017831452 cites W1979420282 @default.
• W2017831452 cites W1981097208 @default.
• W2017831452 cites W1981363848 @default.
• W2017831452 cites W1986357584 @default.
• W2017831452 cites W1992793707 @default.
• W2017831452 cites W1994663540 @default.
• W2017831452 cites W1997976229 @default.
• W2017831452 cites W1998839035 @default.
• W2017831452 cites W2004118951 @default.
• W2017831452 cites W2004123970 @default.
• W2017831452 cites W2006695603 @default.
• W2017831452 cites W2007837117 @default.
• W2017831452 cites W2015376149 @default.
• W2017831452 cites W2022279290 @default.
• W2017831452 cites W2023081218 @default.
• W2017831452 cites W2031081062 @default.
• W2017831452 cites W2047259516 @default.
• W2017831452 cites W2053929600 @default.
• W2017831452 cites W2053956493 @default.
• W2017831452 cites W2056272943 @default.
• W2017831452 cites W2061457233 @default.
• W2017831452 cites W2067166581 @default.
• W2017831452 cites W2067746630 @default.
• W2017831452 cites W2068538092 @default.
• W2017831452 cites W2069300698 @default.
• W2017831452 cites W2072298966 @default.
• W2017831452 cites W2076065290 @default.
• W2017831452 cites W2076409589 @default.
• W2017831452 cites W2086305648 @default.
• W2017831452 cites W2088688801 @default.
• W2017831452 cites W2089351762 @default.
• W2017831452 cites W2100412877 @default.
• W2017831452 cites W2109334244 @default.
• W2017831452 cites W2110741783 @default.
• W2017831452 cites W2119432064 @default.
• W2017831452 cites W2120779052 @default.
• W2017831452 cites W2121614230 @default.
• W2017831452 cites W2129997184 @default.
• W2017831452 cites W2131167630 @default.
• W2017831452 cites W2131722356 @default.
• W2017831452 cites W2142191035 @default.
• W2017831452 cites W2144750899 @default.
• W2017831452 cites W2149402043 @default.
• W2017831452 cites W2313258300 @default.
• W2017831452 cites W2319982487 @default.
• W2017831452 cites W2333423981 @default.
• W2017831452 cites W4242379172 @default.
• W2017831452 cites W4297243831 @default.
• W2017831452 doi "https://doi.org/10.1124/jpet.114.216804" @default.
• W2017831452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25187432" @default.
• W2017831452 hasPublicationYear "2014" @default.
• W2017831452 type Work @default.
• W2017831452 sameAs 2017831452 @default.
• W2017831452 citedByCount "86" @default.
• W2017831452 countsByYear W20178314522015 @default.
• W2017831452 countsByYear W20178314522016 @default.
• W2017831452 countsByYear W20178314522017 @default.
• W2017831452 countsByYear W20178314522018 @default.
• W2017831452 countsByYear W20178314522019 @default.
• W2017831452 countsByYear W20178314522020 @default.
• W2017831452 countsByYear W20178314522021 @default.
• W2017831452 countsByYear W20178314522022 @default.
• W2017831452 countsByYear W20178314522023 @default.
• W2017831452 crossrefType "journal-article" @default.
• W2017831452 hasAuthorship W2017831452A5000414432 @default.
• W2017831452 hasAuthorship W2017831452A5013032842 @default.
• W2017831452 hasAuthorship W2017831452A5015871920 @default.
• W2017831452 hasAuthorship W2017831452A5022761123 @default.
• W2017831452 hasAuthorship W2017831452A5033607802 @default.
• W2017831452 hasAuthorship W2017831452A5043781065 @default.
• W2017831452 hasAuthorship W2017831452A5047992426 @default.
• W2017831452 hasAuthorship W2017831452A5052240068 @default.
• W2017831452 hasAuthorship W2017831452A5057928180 @default.
• W2017831452 hasAuthorship W2017831452A5079738340 @default.

• next