FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017838368> ?p ?o ?g. }

• W2017838368 endingPage "14669" @default.
• W2017838368 startingPage "14664" @default.
• W2017838368 abstract "RNA tertiary structure prediction has been based almost entirely on base-pairing constraints derived from phylogenetic covariation analysis. We describe here a complementary approach, inspired by the Rosetta low-resolution protein structure prediction method, that seeks the lowest energy tertiary structure for a given RNA sequence without using evolutionary information. In a benchmark test of 20 RNA sequences with known structure and lengths of ≈30 nt, the new method reproduces better than 90% of Watson–Crick base pairs, comparable with the accuracy of secondary structure prediction methods. In more than half the cases, at least one of the top five models agrees with the native structure to better than 4 Å rmsd over the backbone. Most importantly, the method recapitulates more than one-third of non-Watson–Crick base pairs seen in the native structures. Tandem stacks of “sheared” base pairs, base triplets, and pseudoknots are among the noncanonical features reproduced in the models. In the cases in which none of the top five models were native-like, higher energy conformations similar to the native structures are still sampled frequently but not assigned low energies. These results suggest that modest improvements in the energy function, together with the incorporation of information from phylogenetic covariance, may allow confident and accurate structure prediction for larger and more complex RNA chains." @default.
• W2017838368 created "2016-06-24" @default.
• W2017838368 creator A5053192926 @default.
• W2017838368 creator A5071548009 @default.
• W2017838368 date "2007-09-11" @default.
• W2017838368 modified "2023-10-11" @default.
• W2017838368 title "Automated <i>de novo</i> prediction of native-like RNA tertiary structures" @default.
• W2017838368 cites W1617413621 @default.
• W2017838368 cites W1970739926 @default.
• W2017838368 cites W1971035426 @default.
• W2017838368 cites W1972715299 @default.
• W2017838368 cites W1972753448 @default.
• W2017838368 cites W1976792261 @default.
• W2017838368 cites W1983534198 @default.
• W2017838368 cites W1985775264 @default.
• W2017838368 cites W1988884185 @default.
• W2017838368 cites W1998618859 @default.
• W2017838368 cites W1999238690 @default.
• W2017838368 cites W2001610344 @default.
• W2017838368 cites W2004219644 @default.
• W2017838368 cites W2004461664 @default.
• W2017838368 cites W2009818318 @default.
• W2017838368 cites W2015187982 @default.
• W2017838368 cites W2015392953 @default.
• W2017838368 cites W2023209608 @default.
• W2017838368 cites W2025388270 @default.
• W2017838368 cites W2031751848 @default.
• W2017838368 cites W2039133207 @default.
• W2017838368 cites W2046982202 @default.
• W2017838368 cites W2048443205 @default.
• W2017838368 cites W2051188149 @default.
• W2017838368 cites W2051713039 @default.
• W2017838368 cites W2052112948 @default.
• W2017838368 cites W2052116279 @default.
• W2017838368 cites W2065057638 @default.
• W2017838368 cites W2072737163 @default.
• W2017838368 cites W2082296224 @default.
• W2017838368 cites W2085623829 @default.
• W2017838368 cites W2087960471 @default.
• W2017838368 cites W2091653936 @default.
• W2017838368 cites W2093519548 @default.
• W2017838368 cites W2095994064 @default.
• W2017838368 cites W2097217058 @default.
• W2017838368 cites W2098276437 @default.
• W2017838368 cites W2105417856 @default.
• W2017838368 cites W2106478835 @default.
• W2017838368 cites W2107334084 @default.
• W2017838368 cites W2116939725 @default.
• W2017838368 cites W2126466006 @default.
• W2017838368 cites W2129842080 @default.
• W2017838368 cites W2138473263 @default.
• W2017838368 cites W2154106236 @default.
• W2017838368 cites W2161968806 @default.
• W2017838368 cites W2417828502 @default.
• W2017838368 doi "https://doi.org/10.1073/pnas.0703836104" @default.
• W2017838368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1955458" @default.
• W2017838368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17726102" @default.
• W2017838368 hasPublicationYear "2007" @default.
• W2017838368 type Work @default.
• W2017838368 sameAs 2017838368 @default.
• W2017838368 citedByCount "383" @default.
• W2017838368 countsByYear W20178383682012 @default.
• W2017838368 countsByYear W20178383682013 @default.
• W2017838368 countsByYear W20178383682014 @default.
• W2017838368 countsByYear W20178383682015 @default.
• W2017838368 countsByYear W20178383682016 @default.
• W2017838368 countsByYear W20178383682017 @default.
• W2017838368 countsByYear W20178383682018 @default.
• W2017838368 countsByYear W20178383682019 @default.
• W2017838368 countsByYear W20178383682020 @default.
• W2017838368 countsByYear W20178383682021 @default.
• W2017838368 countsByYear W20178383682022 @default.
• W2017838368 countsByYear W20178383682023 @default.
• W2017838368 crossrefType "journal-article" @default.
• W2017838368 hasAuthorship W2017838368A5053192926 @default.
• W2017838368 hasAuthorship W2017838368A5071548009 @default.
• W2017838368 hasBestOaLocation W20178383681 @default.
• W2017838368 hasConcept C104317684 @default.
• W2017838368 hasConcept C105130999 @default.
• W2017838368 hasConcept C126142528 @default.
• W2017838368 hasConcept C134306372 @default.
• W2017838368 hasConcept C185581394 @default.
• W2017838368 hasConcept C193252679 @default.
• W2017838368 hasConcept C2778112365 @default.
• W2017838368 hasConcept C33923547 @default.
• W2017838368 hasConcept C41008148 @default.
• W2017838368 hasConcept C42058472 @default.
• W2017838368 hasConcept C54355233 @default.
• W2017838368 hasConcept C552990157 @default.
• W2017838368 hasConcept C55493867 @default.
• W2017838368 hasConcept C62614982 @default.
• W2017838368 hasConcept C67705224 @default.
• W2017838368 hasConcept C70721500 @default.
• W2017838368 hasConcept C75599170 @default.
• W2017838368 hasConcept C85468374 @default.
• W2017838368 hasConcept C86803240 @default.
• W2017838368 hasConceptScore W2017838368C104317684 @default.
• W2017838368 hasConceptScore W2017838368C105130999 @default.

• next