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• W2017841277 abstract "T his study examined the histopathologic features of advanced periodontitis lesions tentatively classified as active or inactive by the selected clinical criteria of bleeding or bleeding and suppuration within 15 seconds of probing or the absence thereof. The Gingival Index, Plaque Index, and pocket fluid flow also were assessed. From 12 human subjects, a total of nine bleeding and five nonbleeding periodontitis lesions were obtained. The biopsies consisted of an extracted tooth and the portion of attached soft tissue which formed the pocket wall at the location where the clinical evaluation was performed. The soft tissue included the entire pocket and junctional epithelia as well as the adjacent normal and infiltrated connective tissue (ICT) and oral epithelium. Major histologic differences were found between the two lesion types. Morphometric point counting using grid intersections revealed that the mean percentage of ICT was consistently much larger in bleeding (55.1 ± (5.1) than in nonbleeding lesions (30.5 ± 7.8). In comparing the composition of the ICT of the two lesion types, significant differences were found between the mean percent volume occupied by plasma cells (68% versus 24%), mononuclear cells (5.5% versus 22%), and extracellular space/connective tissue (18% versus 48%) in the bleeding versus nonbleeding lesions. Nonsignificant differences were present in the volume occupied by polymorphonuclear leukocytes, unidentifiable cells, and vessels in the two lesion types. The pocket epithelium of bleeding lesions consistently demonstrated thinned or ulcerated areas and long, tortuous strands of rete pegs extending deep into the ICT. While showing definite regional variations in polymorphonuclear and mononuclear leukocyte infiltration, the pocket and junctional epithelia of bleeding lesions always contained greater numbers of leukocytes. Bleeding or bleeding combined with suppuration upon probing is therefore indicative of characteristic histopathologic changes in lesions of advanced inflammatory periodontal disease. These changes may relate to the state of activity or inactivity of the disease process in the advanced lesion." @default.
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• W2017841277 date "1982-05-01" @default.
• W2017841277 modified "2023-09-30" @default.
• W2017841277 title "Histometric Comparison of Active and Inactive Lesions of Advanced Periodontitis" @default.
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• W2017841277 doi "https://doi.org/10.1902/jop.1982.53.5.285" @default.
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