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- W2017854299 abstract "Abstract Reported herein is the synthesis and evaluation of anticancer properties of a well-established organometallic protein kinase inhibitor scaffold in which the stereochemical complexity is increased. The investigated ruthenium η5-cyclopentadienyl half-sandwich complexes contain a bidentate pyridocarbazole and a monodentate CO ligand, thereby leading to four different stereoisomers due to the combined presence of ruthenium-centered chirality and planar chirality of the π -coordinated trisubstituted cyclopentadienyl moiety (two diastereomers as mixtures of enantiomers). While one of the two racemic diastereomers turns out to be nontoxic towards cancer cells, the second racemic diastereomer displays high cytotoxicities towards different cancer cell lines in vitro, thus demonstrating the intertwining of organometallic stereochemistry and biological activity." @default.
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- W2017854299 date "2014-11-01" @default.
- W2017854299 modified "2023-10-13" @default.
- W2017854299 title "Synthesis and anticancer activity of ruthenium half-sandwich complexes comprising combined metal centrochirality and planar chirality" @default.
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- W2017854299 doi "https://doi.org/10.1016/j.ica.2014.08.057" @default.
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