Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017854906> ?p ?o ?g. }
- W2017854906 endingPage "401" @default.
- W2017854906 startingPage "395" @default.
- W2017854906 abstract "Because they have been described as strong risk factors for idiopathic recurrent pregnancy losses (RPLs), we assessed the association between the methylenetetrahydrofolate reductase (MTHFR) single-nucleotide polymorphisms (SNPs) C677T and A1298C and hyperhomocysteinemia in Tunisian women with idiopathic RPL. Study subjects comprised 200 patients with more than three consecutive RPLs, and 200 age-matched parous control women. C677T and A1298C SNPs were analyzed by PCR-RFLP analysis, and fasting serum homocysteine was measured with ELISA. The frequency of MTHFR 677T/T (30.0 vs 7.0%) and 1298C/C (13.5 vs 4.0%) genotypes was significantly higher in patients. While it was similar among patients and controls ( P = 0.095), higher homocysteine was seen with the T/T (but not 1298A/C and 1298C/C) genotype among patients and controls compared with non-T/T carriers ( P < 0.05), and in patients vs controls. Higher prevalence of MTHFR 677T/T was seen in late ( P < 0.05) and early-late ( P < 0.001) RPL, while higher prevalence of 1298C/C genotype was seen only in early-late RPL ( P < 0.001), and the prevalence of double heterozygotes was statistically not significant between patients and controls ( P = 0.10; odds ratio = 2.73). Logistic regression analysis showed that, after adjusting for all variables, homozygosity for MTHFR C677T was associated with late ( P < 0.001), and combined early-late ( P < 0.001), while homozygosity for A1298C was associated only with combined early-late ( P = 0.026), as was secondary-level education, which was associated with early ( P = 0.005), late ( P = 0.026) and combined early-late ( P = 0.004) abortions. Homozygosity for MTHFR C677T (late and early-late) and A1298C (early-late) are risk factor for RPLs, irrespectively of total homocysteine levels." @default.
- W2017854906 created "2016-06-24" @default.
- W2017854906 creator A5017076689 @default.
- W2017854906 creator A5021240026 @default.
- W2017854906 creator A5042229393 @default.
- W2017854906 creator A5043504639 @default.
- W2017854906 creator A5045144382 @default.
- W2017854906 creator A5051791762 @default.
- W2017854906 creator A5084672080 @default.
- W2017854906 creator A5085847710 @default.
- W2017854906 date "2006-02-01" @default.
- W2017854906 modified "2023-10-01" @default.
- W2017854906 title "Methylenetetrahydrofolate reductase C677T and A1298C polymorphism and changes in homocysteine concentrations in women with idiopathic recurrent pregnancy losses" @default.
- W2017854906 cites W1496335343 @default.
- W2017854906 cites W1966451334 @default.
- W2017854906 cites W1967162645 @default.
- W2017854906 cites W1975628470 @default.
- W2017854906 cites W1978078542 @default.
- W2017854906 cites W1986559703 @default.
- W2017854906 cites W1986803716 @default.
- W2017854906 cites W1987767223 @default.
- W2017854906 cites W2005452882 @default.
- W2017854906 cites W2023032558 @default.
- W2017854906 cites W2027817026 @default.
- W2017854906 cites W2031262735 @default.
- W2017854906 cites W2048371995 @default.
- W2017854906 cites W2049418341 @default.
- W2017854906 cites W2057680971 @default.
- W2017854906 cites W2066084813 @default.
- W2017854906 cites W2066688265 @default.
- W2017854906 cites W2089205356 @default.
- W2017854906 cites W2092883878 @default.
- W2017854906 cites W2095398374 @default.
- W2017854906 cites W2104985991 @default.
- W2017854906 cites W2106330695 @default.
- W2017854906 cites W2125795934 @default.
- W2017854906 cites W2125909495 @default.
- W2017854906 cites W2151172455 @default.
- W2017854906 cites W2151257471 @default.
- W2017854906 cites W2163768600 @default.
- W2017854906 cites W2165715420 @default.
- W2017854906 cites W2410662570 @default.
- W2017854906 cites W4296980321 @default.
- W2017854906 doi "https://doi.org/10.1530/rep.1.00815" @default.
- W2017854906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16452733" @default.
- W2017854906 hasPublicationYear "2006" @default.
- W2017854906 type Work @default.
- W2017854906 sameAs 2017854906 @default.
- W2017854906 citedByCount "90" @default.
- W2017854906 countsByYear W20178549062012 @default.
- W2017854906 countsByYear W20178549062013 @default.
- W2017854906 countsByYear W20178549062014 @default.
- W2017854906 countsByYear W20178549062015 @default.
- W2017854906 countsByYear W20178549062016 @default.
- W2017854906 countsByYear W20178549062017 @default.
- W2017854906 countsByYear W20178549062018 @default.
- W2017854906 countsByYear W20178549062019 @default.
- W2017854906 countsByYear W20178549062020 @default.
- W2017854906 countsByYear W20178549062021 @default.
- W2017854906 countsByYear W20178549062022 @default.
- W2017854906 countsByYear W20178549062023 @default.
- W2017854906 crossrefType "journal-article" @default.
- W2017854906 hasAuthorship W2017854906A5017076689 @default.
- W2017854906 hasAuthorship W2017854906A5021240026 @default.
- W2017854906 hasAuthorship W2017854906A5042229393 @default.
- W2017854906 hasAuthorship W2017854906A5043504639 @default.
- W2017854906 hasAuthorship W2017854906A5045144382 @default.
- W2017854906 hasAuthorship W2017854906A5051791762 @default.
- W2017854906 hasAuthorship W2017854906A5084672080 @default.
- W2017854906 hasAuthorship W2017854906A5085847710 @default.
- W2017854906 hasBestOaLocation W20178549061 @default.
- W2017854906 hasConcept C104317684 @default.
- W2017854906 hasConcept C126322002 @default.
- W2017854906 hasConcept C134018914 @default.
- W2017854906 hasConcept C134651460 @default.
- W2017854906 hasConcept C135763542 @default.
- W2017854906 hasConcept C146304588 @default.
- W2017854906 hasConcept C151956035 @default.
- W2017854906 hasConcept C153209595 @default.
- W2017854906 hasConcept C153471976 @default.
- W2017854906 hasConcept C156957248 @default.
- W2017854906 hasConcept C181199279 @default.
- W2017854906 hasConcept C2776523773 @default.
- W2017854906 hasConcept C2777090595 @default.
- W2017854906 hasConcept C2779234561 @default.
- W2017854906 hasConcept C43563269 @default.
- W2017854906 hasConcept C54355233 @default.
- W2017854906 hasConcept C55493867 @default.
- W2017854906 hasConcept C71924100 @default.
- W2017854906 hasConcept C86803240 @default.
- W2017854906 hasConcept C90924648 @default.
- W2017854906 hasConceptScore W2017854906C104317684 @default.
- W2017854906 hasConceptScore W2017854906C126322002 @default.
- W2017854906 hasConceptScore W2017854906C134018914 @default.
- W2017854906 hasConceptScore W2017854906C134651460 @default.
- W2017854906 hasConceptScore W2017854906C135763542 @default.
- W2017854906 hasConceptScore W2017854906C146304588 @default.
- W2017854906 hasConceptScore W2017854906C151956035 @default.