FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017859851> ?p ?o ?g. }

• W2017859851 endingPage "655" @default.
• W2017859851 startingPage "647" @default.
• W2017859851 abstract "Early-onset torsion dystonia is an autosomal dominant movement disorder associated with the DYT1 gene (TOR1A) defect which results in a deletion of a glutamic acid residue in the protein torsinA. The pathophysiology of dystonia is poorly understood. Well characterized animal models can help to give insights into the underlying mechanisms and thereby to develop new therapeutics. In the present study, we further characterized transgenic DYT1 mice, which were initially described to exhibit “dystonia-like” postures. In the present study, several behavioural tests in untreated animals did not show strong differences between transgenic and control mice, but nearly all transgenic mice showed “dystonia-like” postures. However, these movements, also observed in control mice, have to be regarded as a clasping reflex. Since dystonia is thought to be related to dopaminergic dysfunctions, pharmacological investigations have been performed to clarify if dopaminergic substances alter motor behaviour in transgenic mice. Chronic treatment with L-DOPA (combined with carbidopa) enhanced the hindlimb claspings only in transgenic mice, while acute applications of drugs, which exert more selective effects on the dopaminergic system, caused similar reactions in transgenic mice and control mice. Therefore, these data do not provide clear evidence for dysfunctions of the dopaminergic system in this mouse model." @default.
• W2017859851 created "2016-06-24" @default.
• W2017859851 creator A5059767732 @default.
• W2017859851 creator A5082199040 @default.
• W2017859851 creator A5084499801 @default.
• W2017859851 creator A5090611944 @default.
• W2017859851 date "2011-02-01" @default.
• W2017859851 modified "2023-09-27" @default.
• W2017859851 title "Behavioural and pharmacological examinations in a transgenic mouse model of early-onset torsion dystonia" @default.
• W2017859851 cites W154554862 @default.
• W2017859851 cites W1824821953 @default.
• W2017859851 cites W1964424631 @default.
• W2017859851 cites W1969279369 @default.
• W2017859851 cites W1973148327 @default.
• W2017859851 cites W1977126867 @default.
• W2017859851 cites W1983262856 @default.
• W2017859851 cites W1983746990 @default.
• W2017859851 cites W1985010074 @default.
• W2017859851 cites W1997720284 @default.
• W2017859851 cites W2004649251 @default.
• W2017859851 cites W2005927762 @default.
• W2017859851 cites W2007598165 @default.
• W2017859851 cites W2008662873 @default.
• W2017859851 cites W2010958487 @default.
• W2017859851 cites W2011994590 @default.
• W2017859851 cites W2016717707 @default.
• W2017859851 cites W2020102061 @default.
• W2017859851 cites W2021649375 @default.
• W2017859851 cites W2033823681 @default.
• W2017859851 cites W2035198471 @default.
• W2017859851 cites W2036052128 @default.
• W2017859851 cites W2045271229 @default.
• W2017859851 cites W2047097758 @default.
• W2017859851 cites W2053114016 @default.
• W2017859851 cites W2054087453 @default.
• W2017859851 cites W2056342955 @default.
• W2017859851 cites W2057275071 @default.
• W2017859851 cites W2057647416 @default.
• W2017859851 cites W2059237846 @default.
• W2017859851 cites W2064598049 @default.
• W2017859851 cites W2064811902 @default.
• W2017859851 cites W2069697322 @default.
• W2017859851 cites W2084752631 @default.
• W2017859851 cites W2088962764 @default.
• W2017859851 cites W2092707982 @default.
• W2017859851 cites W2113803126 @default.
• W2017859851 cites W2119353017 @default.
• W2017859851 cites W2134125288 @default.
• W2017859851 cites W2154011816 @default.
• W2017859851 cites W2157541980 @default.
• W2017859851 cites W2160032181 @default.
• W2017859851 doi "https://doi.org/10.1016/j.pbb.2010.11.005" @default.
• W2017859851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21078339" @default.
• W2017859851 hasPublicationYear "2011" @default.
• W2017859851 type Work @default.
• W2017859851 sameAs 2017859851 @default.
• W2017859851 citedByCount "14" @default.
• W2017859851 countsByYear W20178598512012 @default.
• W2017859851 countsByYear W20178598512013 @default.
• W2017859851 countsByYear W20178598512014 @default.
• W2017859851 countsByYear W20178598512015 @default.
• W2017859851 countsByYear W20178598512016 @default.
• W2017859851 countsByYear W20178598512017 @default.
• W2017859851 countsByYear W20178598512019 @default.
• W2017859851 countsByYear W20178598512021 @default.
• W2017859851 countsByYear W20178598512022 @default.
• W2017859851 crossrefType "journal-article" @default.
• W2017859851 hasAuthorship W2017859851A5059767732 @default.
• W2017859851 hasAuthorship W2017859851A5082199040 @default.
• W2017859851 hasAuthorship W2017859851A5084499801 @default.
• W2017859851 hasAuthorship W2017859851A5090611944 @default.
• W2017859851 hasConcept C102230213 @default.
• W2017859851 hasConcept C104317684 @default.
• W2017859851 hasConcept C134018914 @default.
• W2017859851 hasConcept C137183658 @default.
• W2017859851 hasConcept C141035611 @default.
• W2017859851 hasConcept C169760540 @default.
• W2017859851 hasConcept C2778559928 @default.
• W2017859851 hasConcept C513476851 @default.
• W2017859851 hasConcept C54355233 @default.
• W2017859851 hasConcept C71924100 @default.
• W2017859851 hasConcept C86803240 @default.
• W2017859851 hasConceptScore W2017859851C102230213 @default.
• W2017859851 hasConceptScore W2017859851C104317684 @default.
• W2017859851 hasConceptScore W2017859851C134018914 @default.
• W2017859851 hasConceptScore W2017859851C137183658 @default.
• W2017859851 hasConceptScore W2017859851C141035611 @default.
• W2017859851 hasConceptScore W2017859851C169760540 @default.
• W2017859851 hasConceptScore W2017859851C2778559928 @default.
• W2017859851 hasConceptScore W2017859851C513476851 @default.
• W2017859851 hasConceptScore W2017859851C54355233 @default.
• W2017859851 hasConceptScore W2017859851C71924100 @default.
• W2017859851 hasConceptScore W2017859851C86803240 @default.
• W2017859851 hasIssue "4" @default.
• W2017859851 hasLocation W20178598511 @default.
• W2017859851 hasLocation W20178598512 @default.
• W2017859851 hasOpenAccess W2017859851 @default.
• W2017859851 hasPrimaryLocation W20178598511 @default.

• next