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- W2017881185 abstract "Although the timing with which common epithelial malignancies arise and become established remains a matter of debate, it is clear that by the time they are detected these tumors harbor hundreds of deregulated, aberrantly expressed or mutated genes. This enormous complexity poses formidable challenges to identify gene pathways that are drivers of tumorigenesis, potentially suitable for therapeutic intervention. An alternative approach is to consider cancer pathways as interconnected networks, and search for potential nodal proteins capable of connecting multiple signaling networks of tumor maintenance. We have modeled this approach in advanced prostate cancer, a condition with current limited therapeutic options. We propose that the integration of three signaling networks, including chaperone-mediated mitochondrial homeostasis, integrin-dependent cell signaling, and Runx2-regulated gene expression in the metastatic bone microenvironment plays a critical role in prostate cancer maintenance, and offers novel options for molecular therapy. J. Cell. Biochem. 107: 845–852, 2009. © 2009 Wiley-Liss, Inc." @default.
- W2017881185 created "2016-06-24" @default.
- W2017881185 creator A5008755139 @default.
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- W2017881185 creator A5081199003 @default.
- W2017881185 creator A5082346201 @default.
- W2017881185 creator A5082980616 @default.
- W2017881185 date "2009-08-01" @default.
- W2017881185 modified "2023-10-14" @default.
- W2017881185 title "Prostate cancer regulatory networks" @default.
- W2017881185 cites W116341769 @default.
- W2017881185 cites W1481099429 @default.
- W2017881185 cites W1495045490 @default.
- W2017881185 cites W1522763255 @default.
- W2017881185 cites W1534849470 @default.
- W2017881185 cites W1550247880 @default.
- W2017881185 cites W1576773659 @default.
- W2017881185 cites W1588612022 @default.
- W2017881185 cites W1591646293 @default.
- W2017881185 cites W1604468403 @default.
- W2017881185 cites W1745634660 @default.
- W2017881185 cites W1909302202 @default.
- W2017881185 cites W1963881257 @default.
- W2017881185 cites W1964702114 @default.
- W2017881185 cites W1967394241 @default.
- W2017881185 cites W1973265846 @default.
- W2017881185 cites W1974070035 @default.
- W2017881185 cites W1974128576 @default.
- W2017881185 cites W1980283269 @default.
- W2017881185 cites W1980986250 @default.
- W2017881185 cites W1984547206 @default.
- W2017881185 cites W1986275950 @default.
- W2017881185 cites W1986568749 @default.
- W2017881185 cites W1986832739 @default.
- W2017881185 cites W1994442108 @default.
- W2017881185 cites W1995242599 @default.
- W2017881185 cites W1997994656 @default.
- W2017881185 cites W1998301221 @default.
- W2017881185 cites W1998643392 @default.
- W2017881185 cites W2001888458 @default.
- W2017881185 cites W2002626138 @default.
- W2017881185 cites W2003404796 @default.
- W2017881185 cites W2003911004 @default.
- W2017881185 cites W2003955264 @default.
- W2017881185 cites W2005571058 @default.
- W2017881185 cites W2005886308 @default.
- W2017881185 cites W2009079495 @default.
- W2017881185 cites W2011912935 @default.
- W2017881185 cites W2014656971 @default.
- W2017881185 cites W2015879631 @default.
- W2017881185 cites W2016880167 @default.
- W2017881185 cites W2018836208 @default.
- W2017881185 cites W2021334045 @default.
- W2017881185 cites W2022531767 @default.
- W2017881185 cites W2027636469 @default.
- W2017881185 cites W2029718953 @default.
- W2017881185 cites W2029980980 @default.
- W2017881185 cites W2033178140 @default.
- W2017881185 cites W2036008499 @default.
- W2017881185 cites W2041149077 @default.
- W2017881185 cites W2042667122 @default.
- W2017881185 cites W2047256275 @default.
- W2017881185 cites W2052792754 @default.
- W2017881185 cites W2053338290 @default.
- W2017881185 cites W2055538245 @default.
- W2017881185 cites W2057257618 @default.
- W2017881185 cites W2057639603 @default.
- W2017881185 cites W2058743530 @default.
- W2017881185 cites W2062249523 @default.
- W2017881185 cites W2063099262 @default.
- W2017881185 cites W2063599575 @default.
- W2017881185 cites W2068962767 @default.
- W2017881185 cites W2068973257 @default.
- W2017881185 cites W2070345664 @default.
- W2017881185 cites W2074645605 @default.
- W2017881185 cites W2074800090 @default.
- W2017881185 cites W2076182884 @default.
- W2017881185 cites W2078374613 @default.
- W2017881185 cites W2085419794 @default.
- W2017881185 cites W2087324367 @default.
- W2017881185 cites W2087877138 @default.
- W2017881185 cites W2088629175 @default.
- W2017881185 cites W2090004346 @default.
- W2017881185 cites W2092710950 @default.
- W2017881185 cites W2096088010 @default.
- W2017881185 cites W2097255042 @default.
- W2017881185 cites W2100193180 @default.
- W2017881185 cites W2101977659 @default.
- W2017881185 cites W2102969047 @default.
- W2017881185 cites W2106113955 @default.
- W2017881185 cites W2107610316 @default.
- W2017881185 cites W2109492343 @default.
- W2017881185 cites W2112076644 @default.
- W2017881185 cites W2116177527 @default.
- W2017881185 cites W2116386904 @default.
- W2017881185 cites W2120423759 @default.