Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017881415> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2017881415 endingPage "51" @default.
- W2017881415 startingPage "40" @default.
- W2017881415 abstract "MRL/lpr mice possess an autosomal recessive gene, lpr, which is associated with lymphoproliferation and acceleration of autoimmune disease. Lymphoproliferation has been ascribed to a single gene defect predominantly affecting the T-lymphocyte component of the immune system. MRL/++ mice do not possess the lpr autosomal recessive mutation and do not develop early lymphadenopathy. T-lymphocyte functional activity was studied in these mice using the polyclonal T-cell mitogens PHA and Con A. Our results indicated a significant suppression of the spleen and lymph node response of MRL/lpr mice to these polyclonal mitogens as compared to the MRL/++ response noted as early as 6 weeks of age. In addition, there was a progressive decline in the MRL/lpr spleen and lymph node cell mitogenic responses with increasing age. Spleen and lymph node cells from 20-week MRL/lpr mice were also relatively unresponsive in the mixed lymphocyte culture reaction as compared to cells from MRL/ ++ or BALB/c mice. The in vitro proliferative response of the MRL mice was further examined with respect to possible accessory cell modulation by both macrophages and T cells. It was found that in 20-week MRL/lpr lymph nodes a significant degree of suppression of lymphocyte proliferation could be mediated by the MRL/lpr T cell. Increased lymphocyte proliferation to a mitogenic signal could only be demonstrated in those MRL/lpr mice 3 weeks of age." @default.
- W2017881415 created "2016-06-24" @default.
- W2017881415 creator A5071255834 @default.
- W2017881415 creator A5079175029 @default.
- W2017881415 creator A5085678821 @default.
- W2017881415 date "1981-06-01" @default.
- W2017881415 modified "2023-10-16" @default.
- W2017881415 title "T-cell mediated suppression in the MRL mouse" @default.
- W2017881415 cites W1503287204 @default.
- W2017881415 cites W1513910629 @default.
- W2017881415 cites W1988307311 @default.
- W2017881415 cites W2070133114 @default.
- W2017881415 cites W2084093106 @default.
- W2017881415 cites W2123076414 @default.
- W2017881415 cites W2128344943 @default.
- W2017881415 cites W2134533879 @default.
- W2017881415 cites W2137078804 @default.
- W2017881415 cites W2142360671 @default.
- W2017881415 cites W2142492759 @default.
- W2017881415 cites W2144445149 @default.
- W2017881415 cites W4313309222 @default.
- W2017881415 doi "https://doi.org/10.1016/0008-8749(81)90352-x" @default.
- W2017881415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6455202" @default.
- W2017881415 hasPublicationYear "1981" @default.
- W2017881415 type Work @default.
- W2017881415 sameAs 2017881415 @default.
- W2017881415 citedByCount "9" @default.
- W2017881415 countsByYear W20178814152020 @default.
- W2017881415 crossrefType "journal-article" @default.
- W2017881415 hasAuthorship W2017881415A5071255834 @default.
- W2017881415 hasAuthorship W2017881415A5079175029 @default.
- W2017881415 hasAuthorship W2017881415A5085678821 @default.
- W2017881415 hasConcept C159047783 @default.
- W2017881415 hasConcept C54355233 @default.
- W2017881415 hasConcept C86803240 @default.
- W2017881415 hasConcept C95444343 @default.
- W2017881415 hasConceptScore W2017881415C159047783 @default.
- W2017881415 hasConceptScore W2017881415C54355233 @default.
- W2017881415 hasConceptScore W2017881415C86803240 @default.
- W2017881415 hasConceptScore W2017881415C95444343 @default.
- W2017881415 hasIssue "1" @default.
- W2017881415 hasLocation W20178814151 @default.
- W2017881415 hasLocation W20178814152 @default.
- W2017881415 hasOpenAccess W2017881415 @default.
- W2017881415 hasPrimaryLocation W20178814151 @default.
- W2017881415 hasRelatedWork W1920751942 @default.
- W2017881415 hasRelatedWork W1990804418 @default.
- W2017881415 hasRelatedWork W1991523530 @default.
- W2017881415 hasRelatedWork W2002128513 @default.
- W2017881415 hasRelatedWork W2020824267 @default.
- W2017881415 hasRelatedWork W2031436818 @default.
- W2017881415 hasRelatedWork W2057739827 @default.
- W2017881415 hasRelatedWork W2075354549 @default.
- W2017881415 hasRelatedWork W2082860237 @default.
- W2017881415 hasRelatedWork W2092874662 @default.
- W2017881415 hasVolume "61" @default.
- W2017881415 isParatext "false" @default.
- W2017881415 isRetracted "false" @default.
- W2017881415 magId "2017881415" @default.
- W2017881415 workType "article" @default.