FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017881462> ?p ?o ?g. }

• W2017881462 endingPage "1071" @default.
• W2017881462 startingPage "1066" @default.
• W2017881462 abstract "Background Alkylating agents are commonly used in the treatment of childhood malignant gliomas. Overexpression of O6-methylguanine-DNA methyltransferase (MGMT) constitutes an important mechanism for resistance to such agents, and MGMT status has been associated with outcome in several recent trials. Deficiency in mismatch repair (MMR) function has been implicated in preclinical studies as an additional potential mechanism of resistance to methylating agents, such as temozolomide, independent of tumor MGMT status. However, the frequency of this abnormality as a clinical resistance mechanism in childhood malignant gliomas has not been well characterized. Methods To address this issue, we examined the frequency of microsatellite instability (MSI), a marker of defective MMR, in a series of 68 tumors, derived from newly diagnosed patients treated on the Children's Cancer Group 945 study, and the Children's Oncology Group ACNS0126 and 0423 studies. MSI was assessed using a panel of six microsatellite markers, including BAT-25, BAT-26, CAT-25, D2S123, D5S346, and D17S250. MGMT immunoreactivity was assessed in parallel to allow comparison of the relative incidence of MGMT overexpression and MSI. Results Only three tumors had high-level MSI involving three or more markers; the remainder had no MSI at any of the loci examined. These children did not have unusual features in terms of their outcome. In contrast to the infrequency of MSI, 25 tumors (37%) exhibited MGMT overexpression as assessed by immunohistochemistry. None of the tumors with MSI exhibited overexpression of MGMT. Conclusion MMR deficiency is an infrequent contributor to initial alkylator resistance in children with malignant gliomas. Pediatr Blood Cancer. 2010;55:1066–1071. © 2010 Wiley-Liss, Inc." @default.
• W2017881462 created "2016-06-24" @default.
• W2017881462 creator A5001092978 @default.
• W2017881462 creator A5002782232 @default.
• W2017881462 creator A5023318870 @default.
• W2017881462 creator A5026609192 @default.
• W2017881462 creator A5026714103 @default.
• W2017881462 creator A5027876809 @default.
• W2017881462 creator A5034437611 @default.
• W2017881462 creator A5036048186 @default.
• W2017881462 creator A5052467848 @default.
• W2017881462 creator A5063427987 @default.
• W2017881462 creator A5065795175 @default.
• W2017881462 creator A5070155048 @default.
• W2017881462 creator A5072346018 @default.
• W2017881462 creator A5078484855 @default.
• W2017881462 creator A5080784534 @default.
• W2017881462 date "2010-06-29" @default.
• W2017881462 modified "2023-10-16" @default.
• W2017881462 title "Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: A report from the children's oncology group" @default.
• W2017881462 cites W1884303117 @default.
• W2017881462 cites W1918200890 @default.
• W2017881462 cites W1943407880 @default.
• W2017881462 cites W1968899624 @default.
• W2017881462 cites W1977807996 @default.
• W2017881462 cites W2002378112 @default.
• W2017881462 cites W2010563635 @default.
• W2017881462 cites W2024980830 @default.
• W2017881462 cites W2040827479 @default.
• W2017881462 cites W2042268063 @default.
• W2017881462 cites W2044250902 @default.
• W2017881462 cites W2053535808 @default.
• W2017881462 cites W2057744540 @default.
• W2017881462 cites W2058355285 @default.
• W2017881462 cites W2060937867 @default.
• W2017881462 cites W2076176285 @default.
• W2017881462 cites W2080490195 @default.
• W2017881462 cites W2082103546 @default.
• W2017881462 cites W2090244008 @default.
• W2017881462 cites W2096287682 @default.
• W2017881462 cites W2096428903 @default.
• W2017881462 cites W2097478662 @default.
• W2017881462 cites W2100312975 @default.
• W2017881462 cites W2103594288 @default.
• W2017881462 cites W2105080272 @default.
• W2017881462 cites W2105100844 @default.
• W2017881462 cites W2113729674 @default.
• W2017881462 cites W2120872266 @default.
• W2017881462 cites W2124775785 @default.
• W2017881462 cites W2128637290 @default.
• W2017881462 cites W2128793721 @default.
• W2017881462 cites W2134644359 @default.
• W2017881462 cites W2138656166 @default.
• W2017881462 cites W2147392288 @default.
• W2017881462 cites W2157636873 @default.
• W2017881462 cites W2159416416 @default.
• W2017881462 cites W2167288010 @default.
• W2017881462 cites W2316199641 @default.
• W2017881462 cites W2328946792 @default.
• W2017881462 cites W2331427578 @default.
• W2017881462 cites W2341576311 @default.
• W2017881462 cites W309219819 @default.
• W2017881462 doi "https://doi.org/10.1002/pbc.22634" @default.
• W2017881462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3036982" @default.
• W2017881462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20589656" @default.
• W2017881462 hasPublicationYear "2010" @default.
• W2017881462 type Work @default.
• W2017881462 sameAs 2017881462 @default.
• W2017881462 citedByCount "25" @default.
• W2017881462 countsByYear W20178814622012 @default.
• W2017881462 countsByYear W20178814622013 @default.
• W2017881462 countsByYear W20178814622014 @default.
• W2017881462 countsByYear W20178814622015 @default.
• W2017881462 countsByYear W20178814622016 @default.
• W2017881462 countsByYear W20178814622018 @default.
• W2017881462 countsByYear W20178814622019 @default.
• W2017881462 countsByYear W20178814622020 @default.
• W2017881462 countsByYear W20178814622021 @default.
• W2017881462 crossrefType "journal-article" @default.
• W2017881462 hasAuthorship W2017881462A5001092978 @default.
• W2017881462 hasAuthorship W2017881462A5002782232 @default.
• W2017881462 hasAuthorship W2017881462A5023318870 @default.
• W2017881462 hasAuthorship W2017881462A5026609192 @default.
• W2017881462 hasAuthorship W2017881462A5026714103 @default.
• W2017881462 hasAuthorship W2017881462A5027876809 @default.
• W2017881462 hasAuthorship W2017881462A5034437611 @default.
• W2017881462 hasAuthorship W2017881462A5036048186 @default.
• W2017881462 hasAuthorship W2017881462A5052467848 @default.
• W2017881462 hasAuthorship W2017881462A5063427987 @default.
• W2017881462 hasAuthorship W2017881462A5065795175 @default.
• W2017881462 hasAuthorship W2017881462A5070155048 @default.
• W2017881462 hasAuthorship W2017881462A5072346018 @default.
• W2017881462 hasAuthorship W2017881462A5078484855 @default.
• W2017881462 hasAuthorship W2017881462A5080784534 @default.
• W2017881462 hasBestOaLocation W20178814621 @default.
• W2017881462 hasConcept C104317684 @default.
• W2017881462 hasConcept C120665830 @default.
• W2017881462 hasConcept C121332964 @default.

• next