Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017881566> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2017881566 endingPage "379" @default.
- W2017881566 startingPage "370" @default.
- W2017881566 abstract "We examined the effect of hyperphenylalaninemia induced during the early postweaning period on brain weight, myelin content of brain, and lipid and fatty acid composition of lipids of myelin. Hyperphenylalaninemia was induced in 21-day-old weanling rats by treatment with phenylalanine (Phe) plus p-chlorophenylalanine (PCPA) daily for 30 days. The body weights of control and hyperphenylalaninemic rats did not differ significantly. The brain weight of experimental rats, however, was significantly lower. The reduction in brain weight of Phe + PCPA-treated rats was reflected in lower yields of myelin. The gross composition (proportion of protein and proportion of major lipid components) of myelin from brains of control and experimental rats was not appreciably different. Myelin from hyperphenylalaninemic rat brains, however, contained significantly lower amounts of sulfatide and reduced proportions of unsaturated fatty acids. We conclude that, as in suckling rats, hyperphenylalaninemia induced during the early postweaning period impairs myelination and the myelin synthesized is abnormal with respect to sulfatide content and proportion of unsaturated fatty acids, and as a consequence, the biochemical reactivity and stability of myelin may be altered in hyperphenylalaninemic rat brains." @default.
- W2017881566 created "2016-06-24" @default.
- W2017881566 creator A5027719452 @default.
- W2017881566 creator A5081921021 @default.
- W2017881566 date "1978-09-01" @default.
- W2017881566 modified "2023-09-26" @default.
- W2017881566 title "Effect of postweaning hyperphenylalaninemia on brain development in rats: Myelination, lipid, and fatty acid composition of myelin" @default.
- W2017881566 cites W1984881705 @default.
- W2017881566 cites W2015446302 @default.
- W2017881566 cites W2020558942 @default.
- W2017881566 cites W2026283604 @default.
- W2017881566 cites W2044363752 @default.
- W2017881566 cites W2050866962 @default.
- W2017881566 cites W2057819415 @default.
- W2017881566 cites W2070367085 @default.
- W2017881566 cites W2078713830 @default.
- W2017881566 cites W2087982969 @default.
- W2017881566 cites W2161312100 @default.
- W2017881566 cites W2165082225 @default.
- W2017881566 cites W284393795 @default.
- W2017881566 cites W2087951468 @default.
- W2017881566 doi "https://doi.org/10.1016/0014-4886(78)90253-4" @default.
- W2017881566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/152206" @default.
- W2017881566 hasPublicationYear "1978" @default.
- W2017881566 type Work @default.
- W2017881566 sameAs 2017881566 @default.
- W2017881566 citedByCount "18" @default.
- W2017881566 crossrefType "journal-article" @default.
- W2017881566 hasAuthorship W2017881566A5027719452 @default.
- W2017881566 hasAuthorship W2017881566A5081921021 @default.
- W2017881566 hasConcept C126322002 @default.
- W2017881566 hasConcept C134018914 @default.
- W2017881566 hasConcept C185592680 @default.
- W2017881566 hasConcept C2777431362 @default.
- W2017881566 hasConcept C2778433245 @default.
- W2017881566 hasConcept C2778609137 @default.
- W2017881566 hasConcept C2780968477 @default.
- W2017881566 hasConcept C515207424 @default.
- W2017881566 hasConcept C529278444 @default.
- W2017881566 hasConcept C55493867 @default.
- W2017881566 hasConcept C71924100 @default.
- W2017881566 hasConcept C86803240 @default.
- W2017881566 hasConceptScore W2017881566C126322002 @default.
- W2017881566 hasConceptScore W2017881566C134018914 @default.
- W2017881566 hasConceptScore W2017881566C185592680 @default.
- W2017881566 hasConceptScore W2017881566C2777431362 @default.
- W2017881566 hasConceptScore W2017881566C2778433245 @default.
- W2017881566 hasConceptScore W2017881566C2778609137 @default.
- W2017881566 hasConceptScore W2017881566C2780968477 @default.
- W2017881566 hasConceptScore W2017881566C515207424 @default.
- W2017881566 hasConceptScore W2017881566C529278444 @default.
- W2017881566 hasConceptScore W2017881566C55493867 @default.
- W2017881566 hasConceptScore W2017881566C71924100 @default.
- W2017881566 hasConceptScore W2017881566C86803240 @default.
- W2017881566 hasIssue "2" @default.
- W2017881566 hasLocation W20178815661 @default.
- W2017881566 hasLocation W20178815662 @default.
- W2017881566 hasOpenAccess W2017881566 @default.
- W2017881566 hasPrimaryLocation W20178815661 @default.
- W2017881566 hasRelatedWork W1903956483 @default.
- W2017881566 hasRelatedWork W1990350000 @default.
- W2017881566 hasRelatedWork W1992473014 @default.
- W2017881566 hasRelatedWork W2017881566 @default.
- W2017881566 hasRelatedWork W2019708503 @default.
- W2017881566 hasRelatedWork W2045663970 @default.
- W2017881566 hasRelatedWork W2055417699 @default.
- W2017881566 hasRelatedWork W2095084418 @default.
- W2017881566 hasRelatedWork W2138416651 @default.
- W2017881566 hasRelatedWork W2248524982 @default.
- W2017881566 hasVolume "61" @default.
- W2017881566 isParatext "false" @default.
- W2017881566 isRetracted "false" @default.
- W2017881566 magId "2017881566" @default.
- W2017881566 workType "article" @default.