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- W2017881711 abstract "Abstract The effects of human recombinant basic fibroblastic growth factor (bFGF) on the secretion, viability, proliferation, attachment and morphology of ten dispersed human clinically non-functional (NF) adenomas were examined in vitro . Four clinically NF adenomas secreting FSH and/or LH in vitro were unaffected by 10 n m bFGF over a 4-h period. Over 4 days 10 nm bFGF stimulated LH secretion (66% and 72%, P <0·01) from two out of seven clinically NF adenomas secreting LH, whilst FSH (three tumours) and α-subunit secretion (three tumours) were unaffected. One adenoma co-secreting LH and α-subunit and one secreting LH alone were studied over 21 days; LH secretion fell progressively, but the decline was significantly less ( P <0·05) with bFGF (10 n m ) treatment after 14 and 21 days in both adenomas, whilst the fall in α-subunit secretion was unaffected by bFGF treatment. A 24-h GnRH test performed at the start and end of the 21-day period in one of these tumours showed an increase in both basal and stimulated LH secretion in the bFGF-treated group over control (124%, P <0·001). There was no effect of bFGF (10 n m ) on viability, S-phase proliferation, attachment or morphology of adenoma cells over a 4-day period. These results suggest that bFGF has a role in tumorous LH secretion from these adenomas, but is not mitogenic (at least over 4 days) and is without effect on other parameters of in vitro differentiated function. Journal of Endocrinology (1995) 144, 173–178" @default.
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- W2017881711 date "1995-01-01" @default.
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- W2017881711 title "Effects of basic fibroblastic growth factor on the function and proliferation of human clinically non-functional pituitary adenomas which secreted glycoprotein hormones in vitro" @default.
- W2017881711 doi "https://doi.org/10.1677/joe.0.1440173" @default.
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