FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017882625> ?p ?o ?g. }

• W2017882625 endingPage "777" @default.
• W2017882625 startingPage "772" @default.
• W2017882625 abstract "Background: The trauma literature is inconsistent in its conclusions and recommendations concerning the influence of oral anticoagulation on outcomes after injury. Some report worse outcomes, whereas others showed no effect. We approached this problem by using the patients’ admission international normalized ratio (INR) values to document anticoagulation and hypothesized that warfarin anticoagulation is associated with increased mortality after trauma in the elderly. We further questioned the cost-effectiveness of admission INR testing. Methods: We conducted a retrospective review of 3,242 trauma patients aged 50 and older. INR data were used as a surrogate for warfarin anticoagulation and was related to age, sex, and Injury Severity Scale score (ISS) to analyze effects on mortality. Logistic regression was used to perform multivariate analyses. INR costs were summed from all laboratory department costs. Results: Of the 3,242 elderly injured patients, admission INR was obtained in 1,251 patients. One hundred and two patients had an “elevated” INR of >1.5. Mortality for those with an INR >1.5 was 22.6%, versus 8.2% for those with an INR <1.5 (p < 0.0001). The logistic regression gave an age and ISS adjusted odds of death of 30% for a one unit increase in INR (OR 1.3, 95% CI 1.1–1.5; p value 0.002). This correlates to an age and injury score adjusted odds of death of 2.5 for an INR >1.5 (95% CI 1.2–4.2; p value 0.014). INR cost was estimated at $5 per blood draw. Conclusion: After adjusting for age, gender, and ISS, anticoagulation was associated with increased overall mortality. Elderly patients are commonly anticoagulated and anticoagulation is a therapeutically reversible risk factor. Considering the increasing number of indications for and prevalence of anticoagulation, the low cost of an INR and the potential reduction in costs associated with traumatic brain injury, these data support the recommendation to assess a coagulation profile in elderly trauma patients to identify earlier those in need of closer monitoring and a more aggressive reversal of their anticoagulation." @default.
• W2017882625 created "2016-06-24" @default.
• W2017882625 creator A5045674083 @default.
• W2017882625 creator A5060451007 @default.
• W2017882625 creator A5080010894 @default.
• W2017882625 creator A5087253902 @default.
• W2017882625 date "2008-10-01" @default.
• W2017882625 modified "2023-10-03" @default.
• W2017882625 title "The Necessity to Assess Anticoagulation Status in Elderly Injured Patients" @default.
• W2017882625 cites W1998190480 @default.
• W2017882625 cites W2002470351 @default.
• W2017882625 cites W2006149651 @default.
• W2017882625 cites W2007564671 @default.
• W2017882625 cites W2088392418 @default.
• W2017882625 cites W2132505348 @default.
• W2017882625 cites W2322849828 @default.
• W2017882625 cites W2600339308 @default.
• W2017882625 cites W34230371 @default.
• W2017882625 doi "https://doi.org/10.1097/ta.0b013e3181877ff7" @default.
• W2017882625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18849789" @default.
• W2017882625 hasPublicationYear "2008" @default.
• W2017882625 type Work @default.
• W2017882625 sameAs 2017882625 @default.
• W2017882625 citedByCount "31" @default.
• W2017882625 countsByYear W20178826252012 @default.
• W2017882625 countsByYear W20178826252013 @default.
• W2017882625 countsByYear W20178826252014 @default.
• W2017882625 countsByYear W20178826252015 @default.
• W2017882625 countsByYear W20178826252016 @default.
• W2017882625 countsByYear W20178826252017 @default.
• W2017882625 countsByYear W20178826252018 @default.
• W2017882625 countsByYear W20178826252019 @default.
• W2017882625 countsByYear W20178826252021 @default.
• W2017882625 countsByYear W20178826252022 @default.
• W2017882625 countsByYear W20178826252023 @default.
• W2017882625 crossrefType "journal-article" @default.
• W2017882625 hasAuthorship W2017882625A5045674083 @default.
• W2017882625 hasAuthorship W2017882625A5060451007 @default.
• W2017882625 hasAuthorship W2017882625A5080010894 @default.
• W2017882625 hasAuthorship W2017882625A5087253902 @default.
• W2017882625 hasConcept C126322002 @default.
• W2017882625 hasConcept C143095724 @default.
• W2017882625 hasConcept C151956035 @default.
• W2017882625 hasConcept C156957248 @default.
• W2017882625 hasConcept C167135981 @default.
• W2017882625 hasConcept C190385971 @default.
• W2017882625 hasConcept C194828623 @default.
• W2017882625 hasConcept C2776301958 @default.
• W2017882625 hasConcept C2779161974 @default.
• W2017882625 hasConcept C3017944768 @default.
• W2017882625 hasConcept C71924100 @default.
• W2017882625 hasConcept C85004164 @default.
• W2017882625 hasConceptScore W2017882625C126322002 @default.
• W2017882625 hasConceptScore W2017882625C143095724 @default.
• W2017882625 hasConceptScore W2017882625C151956035 @default.
• W2017882625 hasConceptScore W2017882625C156957248 @default.
• W2017882625 hasConceptScore W2017882625C167135981 @default.
• W2017882625 hasConceptScore W2017882625C190385971 @default.
• W2017882625 hasConceptScore W2017882625C194828623 @default.
• W2017882625 hasConceptScore W2017882625C2776301958 @default.
• W2017882625 hasConceptScore W2017882625C2779161974 @default.
• W2017882625 hasConceptScore W2017882625C3017944768 @default.
• W2017882625 hasConceptScore W2017882625C71924100 @default.
• W2017882625 hasConceptScore W2017882625C85004164 @default.
• W2017882625 hasIssue "4" @default.
• W2017882625 hasLocation W20178826251 @default.
• W2017882625 hasLocation W20178826252 @default.
• W2017882625 hasOpenAccess W2017882625 @default.
• W2017882625 hasPrimaryLocation W20178826251 @default.
• W2017882625 hasRelatedWork W1993555144 @default.
• W2017882625 hasRelatedWork W2015191509 @default.
• W2017882625 hasRelatedWork W2037611947 @default.
• W2017882625 hasRelatedWork W2102363218 @default.
• W2017882625 hasRelatedWork W2164301666 @default.
• W2017882625 hasRelatedWork W2411462715 @default.
• W2017882625 hasRelatedWork W2490743879 @default.
• W2017882625 hasRelatedWork W2576673842 @default.
• W2017882625 hasRelatedWork W92486268 @default.
• W2017882625 hasRelatedWork W4210444951 @default.
• W2017882625 hasVolume "65" @default.
• W2017882625 isParatext "false" @default.
• W2017882625 isRetracted "false" @default.
• W2017882625 magId "2017882625" @default.
• W2017882625 workType "article" @default.