FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017883606> ?p ?o ?g. }

• W2017883606 endingPage "707" @default.
• W2017883606 startingPage "692" @default.
• W2017883606 abstract "Die (2′→ 5′)- und (3′→ 5′)-verknüpften Dinucleosid-monophosphate 3e und 2e des Tubercidins werden aus den Vorstufen 1b oder 1c und 1a durch Kondensation mit Dichlormethoxyphosphan erhalten. Mit 1H-NMR-Untersuchungen konnte gezeigt werden, daß die Nucleobasen eine andere Konformation als im (2′→ 5′)- oder (3′→ 4′)ApA einnehmen. Aus thermodynamischen Parametern sowie der Hypochromizität ergibt sich für 3e eine größere Basenwechselwirkung als für 2e. Einzelstrang-spezifische Nuclease S1 spaltet 2e deutlich schneller als (3′→ 5′)ApA und reagiert damit empfindlich auf die Aglyconmodifikation. Die Kondensation des 5′-entschützten Dimers 3b mit dem Monomer 1c, gefolgt von der Abspaltung der Schutzgruppen, führt zu (2′→ 5′)-TupTupTu (4e). Dies stellt ein Analogon von (2′→ 5′)ApApA dar, das als Triphosphat antiviral wirksam ist. (2′→5′) and (3′→′)-Tubercidylyl-tubercidins - Synthesis via Phosphite Triester and Investigation of Secondary Structure The (2′→ 5′)- and (3′→5′)-linked dinucleoside monophosphates 3e and 2e of tubercidin were synthesized by condensation of the monomers 1c or 1b with dichloromethoxyphosphane. By 1H NMR studies it could be demonstrated that the conformation of these nucleobases is different from that in (3′→ 5′)ApA and (2′→ 5′)ApA. From thermodynamic parameters, as well as from hypochromicity, a stronger base – base interaction in 3e than in 2e was deduced. Single-strand specific nuclease S1 hydrolyses 2e at a much higher rate than (3′→ 5′)ApA demonstrating that the enzyme is sensitive towards modification of the aglycone. Condensation of the 5′-deprotected dimer 3b with the monomer 1c followed by complete deprotection yields (2′→ 5′)TupTuTu (4e), which is an analogue of (2′→ 5′)ApApA, the triphosphate of which is antivirally active." @default.
• W2017883606 created "2016-06-24" @default.
• W2017883606 creator A5036908659 @default.
• W2017883606 creator A5081361630 @default.
• W2017883606 creator A5082589907 @default.
• W2017883606 date "1984-04-12" @default.
• W2017883606 modified "2023-10-16" @default.
• W2017883606 title "(2′→ 5′)- und (3′→ 5′)- Tubercidylyl-tubercidine – Synthese über Phosphit- Triester und Untersuchungen zur Sekundärstruktur," @default.
• W2017883606 cites W1215340667 @default.
• W2017883606 cites W1979851464 @default.
• W2017883606 cites W1982350866 @default.
• W2017883606 cites W1983403076 @default.
• W2017883606 cites W1987455836 @default.
• W2017883606 cites W1990747892 @default.
• W2017883606 cites W1991178337 @default.
• W2017883606 cites W1993708100 @default.
• W2017883606 cites W1996815002 @default.
• W2017883606 cites W2019014169 @default.
• W2017883606 cites W2022719676 @default.
• W2017883606 cites W2027677803 @default.
• W2017883606 cites W2039678175 @default.
• W2017883606 cites W2046602444 @default.
• W2017883606 cites W2047617724 @default.
• W2017883606 cites W2051487716 @default.
• W2017883606 cites W2052093024 @default.
• W2017883606 cites W2054546881 @default.
• W2017883606 cites W2054979333 @default.
• W2017883606 cites W2057688653 @default.
• W2017883606 cites W2059081846 @default.
• W2017883606 cites W2067031652 @default.
• W2017883606 cites W2072905097 @default.
• W2017883606 cites W2084621821 @default.
• W2017883606 cites W2087795360 @default.
• W2017883606 cites W2093640723 @default.
• W2017883606 cites W2112834292 @default.
• W2017883606 cites W2116571289 @default.
• W2017883606 cites W2158805724 @default.
• W2017883606 cites W2468070459 @default.
• W2017883606 cites W2488927919 @default.
• W2017883606 cites W2489812918 @default.
• W2017883606 doi "https://doi.org/10.1002/jlac.198419840407" @default.
• W2017883606 hasPublicationYear "1984" @default.
• W2017883606 type Work @default.
• W2017883606 sameAs 2017883606 @default.
• W2017883606 citedByCount "9" @default.
• W2017883606 crossrefType "journal-article" @default.
• W2017883606 hasAuthorship W2017883606A5036908659 @default.
• W2017883606 hasAuthorship W2017883606A5081361630 @default.
• W2017883606 hasAuthorship W2017883606A5082589907 @default.
• W2017883606 hasConcept C166940927 @default.
• W2017883606 hasConcept C178790620 @default.
• W2017883606 hasConcept C185592680 @default.
• W2017883606 hasConcept C2779546866 @default.
• W2017883606 hasConcept C521977710 @default.
• W2017883606 hasConcept C71240020 @default.
• W2017883606 hasConceptScore W2017883606C166940927 @default.
• W2017883606 hasConceptScore W2017883606C178790620 @default.
• W2017883606 hasConceptScore W2017883606C185592680 @default.
• W2017883606 hasConceptScore W2017883606C2779546866 @default.
• W2017883606 hasConceptScore W2017883606C521977710 @default.
• W2017883606 hasConceptScore W2017883606C71240020 @default.
• W2017883606 hasIssue "4" @default.
• W2017883606 hasLocation W20178836061 @default.
• W2017883606 hasOpenAccess W2017883606 @default.
• W2017883606 hasPrimaryLocation W20178836061 @default.
• W2017883606 hasRelatedWork W1972220625 @default.
• W2017883606 hasRelatedWork W2037523448 @default.
• W2017883606 hasRelatedWork W2048171333 @default.
• W2017883606 hasRelatedWork W2058139511 @default.
• W2017883606 hasRelatedWork W2126853599 @default.
• W2017883606 hasRelatedWork W2127915608 @default.
• W2017883606 hasRelatedWork W2953251415 @default.
• W2017883606 hasRelatedWork W2963093740 @default.
• W2017883606 hasRelatedWork W4253249727 @default.
• W2017883606 hasRelatedWork W894066805 @default.
• W2017883606 hasVolume "1984" @default.
• W2017883606 isParatext "false" @default.
• W2017883606 isRetracted "false" @default.
• W2017883606 magId "2017883606" @default.
• W2017883606 workType "article" @default.