FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017885661> ?p ?o ?g. }

• W2017885661 endingPage "2679" @default.
• W2017885661 startingPage "2671" @default.
• W2017885661 abstract "This study explores the role of mevalonate inhibitors in the activation of NF-kbeta and the induction of inducible nitric oxide synthase (iNOS) and cytokines (TNF-alpha, IL-1beta, and IL-6) in rat primary astrocytes, microglia, and macrophages. Lovastatin and sodium phenylacetate (NaPA) were found to inhibit LPS- and cytokine-mediated production of NO and expression of iNOS in rat primary astrocytes; this inhibition was not due to depletion of end products of mevalonate pathway (e.g., cholesterol and ubiquinone). Reversal of the inhibitory effect of lovastatin on LPS-induced iNOS expression by mevalonate and farnesyl pyrophosphate and reversal of the inhibitory effect of NaPA on LPS-induced iNOS expression by farnesyl pyrophosphate, however, suggests a role of farnesylation in the LPS-mediated induction of iNOS. The inhibition of LPS-mediated induction of iNOS by FPT inhibitor II, an inhibitor of Ras farnesyl protein transferase, suggests that farnesylation of p21(ras) or other proteins regulates the induction of iNOS. Inhibition of LPS-mediated activation of NF-kbeta by lovastatin, NaPA, and FPT inhibitor II in astrocytes indicates that the observed inhibition of iNOS expression is mediated via inhibition of NF-kbeta activation. In addition to iNOS, lovastatin and NaPA also inhibited LPS-induced expression of TNF-alpha, IL-1beta, and IL-6 in rat primary astrocytes, microglia, and macrophages. This study delineates a novel role of the mevalonate pathway in controlling the expression of iNOS and different cytokines in rat astrocytes, microglia, and macrophages that may be important in developing therapeutics against cytokine- and NO-mediated neurodegenerative diseases." @default.
• W2017885661 created "2016-06-24" @default.
• W2017885661 creator A5029013158 @default.
• W2017885661 creator A5032747758 @default.
• W2017885661 creator A5085066634 @default.
• W2017885661 creator A5087133073 @default.
• W2017885661 date "1997-12-01" @default.
• W2017885661 modified "2023-09-25" @default.
• W2017885661 title "Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages." @default.
• W2017885661 cites W114365888 @default.
• W2017885661 cites W1500094754 @default.
• W2017885661 cites W1501941180 @default.
• W2017885661 cites W1519301821 @default.
• W2017885661 cites W1551967777 @default.
• W2017885661 cites W1553734064 @default.
• W2017885661 cites W1591881963 @default.
• W2017885661 cites W1646206347 @default.
• W2017885661 cites W1679229316 @default.
• W2017885661 cites W1767142804 @default.
• W2017885661 cites W1805879606 @default.
• W2017885661 cites W1834041853 @default.
• W2017885661 cites W1932535232 @default.
• W2017885661 cites W1944330918 @default.
• W2017885661 cites W1966191179 @default.
• W2017885661 cites W1979230311 @default.
• W2017885661 cites W1982707988 @default.
• W2017885661 cites W1988726352 @default.
• W2017885661 cites W1993243592 @default.
• W2017885661 cites W2006705806 @default.
• W2017885661 cites W2007437940 @default.
• W2017885661 cites W2011056756 @default.
• W2017885661 cites W2011564032 @default.
• W2017885661 cites W2011769338 @default.
• W2017885661 cites W2016687652 @default.
• W2017885661 cites W2059994807 @default.
• W2017885661 cites W2063388001 @default.
• W2017885661 cites W2070288036 @default.
• W2017885661 cites W2071124826 @default.
• W2017885661 cites W2079595986 @default.
• W2017885661 cites W2079982783 @default.
• W2017885661 cites W2089906643 @default.
• W2017885661 cites W2107204664 @default.
• W2017885661 cites W2108999152 @default.
• W2017885661 cites W2128635872 @default.
• W2017885661 cites W2140318963 @default.
• W2017885661 cites W2148582802 @default.
• W2017885661 cites W2155599970 @default.
• W2017885661 cites W2171376761 @default.
• W2017885661 cites W2198456767 @default.
• W2017885661 cites W2418342481 @default.
• W2017885661 cites W250613533 @default.
• W2017885661 doi "https://doi.org/10.1172/jci119812" @default.
• W2017885661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/508470" @default.
• W2017885661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9389730" @default.
• W2017885661 hasPublicationYear "1997" @default.
• W2017885661 type Work @default.
• W2017885661 sameAs 2017885661 @default.
• W2017885661 citedByCount "549" @default.
• W2017885661 countsByYear W20178856612012 @default.
• W2017885661 countsByYear W20178856612013 @default.
• W2017885661 countsByYear W20178856612014 @default.
• W2017885661 countsByYear W20178856612015 @default.
• W2017885661 countsByYear W20178856612016 @default.
• W2017885661 countsByYear W20178856612017 @default.
• W2017885661 countsByYear W20178856612018 @default.
• W2017885661 countsByYear W20178856612019 @default.
• W2017885661 countsByYear W20178856612020 @default.
• W2017885661 countsByYear W20178856612021 @default.
• W2017885661 countsByYear W20178856612022 @default.
• W2017885661 countsByYear W20178856612023 @default.
• W2017885661 crossrefType "journal-article" @default.
• W2017885661 hasAuthorship W2017885661A5029013158 @default.
• W2017885661 hasAuthorship W2017885661A5032747758 @default.
• W2017885661 hasAuthorship W2017885661A5085066634 @default.
• W2017885661 hasAuthorship W2017885661A5087133073 @default.
• W2017885661 hasBestOaLocation W20178856611 @default.
• W2017885661 hasConcept C112243037 @default.
• W2017885661 hasConcept C134018914 @default.
• W2017885661 hasConcept C181199279 @default.
• W2017885661 hasConcept C185592680 @default.
• W2017885661 hasConcept C203014093 @default.
• W2017885661 hasConcept C2776914184 @default.
• W2017885661 hasConcept C2776990775 @default.
• W2017885661 hasConcept C2777622882 @default.
• W2017885661 hasConcept C2778163477 @default.
• W2017885661 hasConcept C2778690821 @default.
• W2017885661 hasConcept C2778827360 @default.
• W2017885661 hasConcept C2779830541 @default.
• W2017885661 hasConcept C2779982574 @default.
• W2017885661 hasConcept C2780361610 @default.
• W2017885661 hasConcept C2780940807 @default.
• W2017885661 hasConcept C519581460 @default.
• W2017885661 hasConcept C553450214 @default.
• W2017885661 hasConcept C55493867 @default.
• W2017885661 hasConcept C57790582 @default.
• W2017885661 hasConcept C86803240 @default.
• W2017885661 hasConcept C98274493 @default.
• W2017885661 hasConceptScore W2017885661C112243037 @default.

• next