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• W2017892023 endingPage "4077" @default.
• W2017892023 startingPage "4071" @default.
• W2017892023 abstract "Cyclopentane derivatives, designated as BCX-1812, BCX-1827, BCX-1898, and BCX-1923, were tested in parallel with oseltamivir carboxylate and zanamivir for the in vivo activity in mice infected with A/Turkey/Mas/76 X A/Beijing/32/92 (H6N2) influenza virus. The compounds were tested orally and intranasally at different dose levels. BCX-1812, BCX-1827, and BCX-1923 showed more than 50% protection at 1 mg/kg/day dose level on oral treatment. The intranasal treatment was 100% effective even at 0.01 mg/kg/day for all four compounds. On comparison with oseltamivir carboxylate and zanamivir, these four cyclopentane derivatives have shown equal or better efficacies. The synthesis of two new compounds, BCX-1898 and BCX-1923, is also described." @default.
• W2017892023 created "2016-06-24" @default.
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• W2017892023 date "2005-06-01" @default.
• W2017892023 modified "2023-10-09" @default.
• W2017892023 title "Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo" @default.
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• W2017892023 doi "https://doi.org/10.1016/j.bmc.2005.03.048" @default.
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