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• W2017896232 abstract "Nicotine, pyrrolidines and cyclic imines induced the release of biogenic amines from mouse neoplastic mast cells. Alkaline conditions were required to convert the releasing agents to the form of their free base thus making available the 2s-electron pair of the molecule's alicyclic nitrogen atom for interaction with the cells' trigger sites. The potency of the compounds as releasing agents was directly related to their basicity. The elevated pH was also needed to convert the cryptic or conformationally unreactive trigger site to an available or reactive form that permitted the interaction with the releasing agent to occur." @default.
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• W2017896232 date "1974-08-01" @default.
• W2017896232 modified "2023-09-27" @default.
• W2017896232 title "Structural requirements for nicotine and cyclic imine-induced amine release from neoplastic mast cells" @default.
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• W2017896232 doi "https://doi.org/10.1016/0006-2952(74)90553-x" @default.
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