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- W2017902870 abstract "A case-control study was conducted to evaluate the role of IL-4 VNTR polymorphism in asthma that has been associated with various inflammatory diseases worldwide. This is the first case-control study conducted in India, investigating the role of IL-4 VNTR polymorphism in asthma pathogenesis. A case-control study was performed with a total of 824 adult subjects, inducting 410 asthma patients and 414 healthy controls from North India. The genotypes were identified by polymerase chain reaction. Statistical analysis for the IL-4 VNTR polymorphism revealed that the Rp1 allele was significantly associated with asthma with OR = 1.47, 95% CI (1.11–1.94) and p = 0.005. The Rp1/Rp1 homozygous mutant genotype posed a high risk towards asthma with OR = 2.39, 95% CI (0.96–6.14) and p = 0.040. The Rp2/Rp1 heterozygous genotype also posed a risk towards asthma with OR = 1.39, 95% CI (1.00–1.94) and p = 0.040. Most of the phenotypic traits were significantly associated with the disease. IL-4 VNTR polymorphism is a high risk factor for asthma in the studied North Indian population." @default.
- W2017902870 created "2016-06-24" @default.
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- W2017902870 date "2014-03-01" @default.
- W2017902870 modified "2023-10-16" @default.
- W2017902870 title "High risk association of IL-4 VNTR polymorphism with asthma in a North Indian population" @default.
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- W2017902870 doi "https://doi.org/10.1016/j.cyto.2014.01.002" @default.
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