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• W2017906462 abstract "OBJECTIVE: Insulin resistance is known to be related to PCOS even thought the mechanism is not fully understood. Recently, mitochondrial function has been associated with glucose metabolism and the maintenance of mitochondrial DNA (mtDNA) copy number is essential for the preservation of mitochondrial function. The aim of this study was to investigate the potential role of mtDNA copy number in women with PCOS.DESIGN: Cross-sectional study.MATERIALS AND METHODS: 51 women with PCOS and 58 healthy women, all of whom were age- and weight-matched, were studied. Blood was obtained to determine mtDNA copy number as well as metabolic and hormonal parameters and indices of IR (fasting insulin, and the homeostasis model assessment of insulin resistance [HOMA-IR]), indices of insulin sensitivity (IS) (fasting glucose/fasting insulin [GF/IF], and the quantitative insulin sensitivity check index [QUICKI]) were calculated for each subject.RESULTS: The mtDNA copy number were lower (P <0.01) in women with PCOS after adjusting for age, body mass index (BMI), mean blood pressure, triglyceride (TG), high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, fasting glucose, fasting insulin, LH/FSH, total testosterone and SHBG levels. PCOS status was the strongest predictor of lower mtDNA copy number. In both the PCOS and control groups, mtDNA copy number was negatively correlated with IR and positively correlated with IS indices. In addition, mtDNA copy number was significantly correlated with triglyceride and SHBG in PCOS (P =0.01 and P= 0.01, respectively).CONCLUSION: Lower mtDNA copy number in the PCOS group, when compared to the non-PCOS group, was observed, and this difference may play a role in the pathophysiology observed in women with PCOS. Further studies are needed to clarify the role of mitochondrial function in these women. OBJECTIVE: Insulin resistance is known to be related to PCOS even thought the mechanism is not fully understood. Recently, mitochondrial function has been associated with glucose metabolism and the maintenance of mitochondrial DNA (mtDNA) copy number is essential for the preservation of mitochondrial function. The aim of this study was to investigate the potential role of mtDNA copy number in women with PCOS. DESIGN: Cross-sectional study. MATERIALS AND METHODS: 51 women with PCOS and 58 healthy women, all of whom were age- and weight-matched, were studied. Blood was obtained to determine mtDNA copy number as well as metabolic and hormonal parameters and indices of IR (fasting insulin, and the homeostasis model assessment of insulin resistance [HOMA-IR]), indices of insulin sensitivity (IS) (fasting glucose/fasting insulin [GF/IF], and the quantitative insulin sensitivity check index [QUICKI]) were calculated for each subject. RESULTS: The mtDNA copy number were lower (P <0.01) in women with PCOS after adjusting for age, body mass index (BMI), mean blood pressure, triglyceride (TG), high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, fasting glucose, fasting insulin, LH/FSH, total testosterone and SHBG levels. PCOS status was the strongest predictor of lower mtDNA copy number. In both the PCOS and control groups, mtDNA copy number was negatively correlated with IR and positively correlated with IS indices. In addition, mtDNA copy number was significantly correlated with triglyceride and SHBG in PCOS (P =0.01 and P= 0.01, respectively). CONCLUSION: Lower mtDNA copy number in the PCOS group, when compared to the non-PCOS group, was observed, and this difference may play a role in the pathophysiology observed in women with PCOS. Further studies are needed to clarify the role of mitochondrial function in these women." @default.
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• W2017906462 date "2010-09-01" @default.
• W2017906462 modified "2023-09-26" @default.
• W2017906462 title "Mitochontrial DNA copy number in peripheral blood in polycystic ovarian syndrome" @default.
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• W2017906462 doi "https://doi.org/10.1016/j.fertnstert.2010.07.746" @default.
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