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- W2017906719 abstract "Despite modern advances in antibiotic therapy and cardiovascular support, septic shock remains a condition plagued by a high mortality rate, estimated at 40- 60%. The pathogenesis of septic shock involves a complex orchestration of cytokines which lead to vasodilation, increased capillary permeability, and disturbances of metabolism. The major clinical features include hypotension, tissue hypoperfusion, myocardial depression, and organ failures. Cur-rent therapy focuses on early broad-spectrum antibiotic treatment, correction of hypovolemia, and appro-priate use of vasopressor and/or inotropic agents. Experimental attempts to intervene in the septic cytokine cascade hold promise, but none have shown a definitive clinical benefit. This review examines the pathogenesis, clinical features, current therapeutic approaches, and future prospects for this serious prob-lem." @default.
- W2017906719 created "2016-06-24" @default.
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- W2017906719 date "1997-10-25" @default.
- W2017906719 modified "2023-09-26" @default.
- W2017906719 title "Pathogenesis and Management of Septic Shock" @default.
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- W2017906719 doi "https://doi.org/10.15273/dmj.vol25no2.3729" @default.
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