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• W2017912576 abstract "<h2>Abstract</h2> To assess the effect of carteolol, a β-blocker, on ischemia and reperfusion, changes in the ultrastructure of myocytes and energy metabolism were studied by ³¹P-NMR in 41 pig hearts without collateral circulation. The left anterior descending coronary artery was occluded for 20 min and reperfused for 120 min in three groups: seven pigs (group 1, no treatment with carteolol; group 2, pre-ischemia treatment with carteolol (10 μg/kg); group 3, post-ischemia treatment with carteolol before reperfusion). Other groups of five pigs were killed after 120 min of ischemia (group 4, no treatment; group 5, pre-ischemia treatment) or 20 min of ischemia (group 6, no treatment; group 7, pre-ischemia treatment). After 20 min of ischemia, ATP was higher in groups 2 (76 ± 9% of the baseline value) than in group 1 (59 ± 5%) and group 3 (60 ± 10%). However, the difference disappeared after 30 min of ischemia. After 120 min of reperfusion, ATP showed much better recovery in group 2 (92 ± 9%) than in groups 1 (66 ± 7%) and 3 (68 ± 10%). Ischemic injury, as viewed by light and electron microscopy, was milder in group 7 than in group 6 after 20 min occlusion, but the myocytes were almost normal after 120 min reperfusion in groups 1 to 3. The heart rate, blood pressure and rate pressure product showed no significant difference among the groups. These results indicate that pre-ischemia treatment with carteolol provided protection against ischemic cellular injury and accelerated the repletion of ATP during reperfusion, but the post-ischemia treatment did not lead to recovery of ATP. Therefore, the favorable effect during reperfusion of pre-ischemia treatment with carteolol depends on its protective effect during ischemia." @default.
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• W2017912576 date "1992-01-01" @default.
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• W2017912576 title "Protective effect of carteolol, a β-blocker, on myocardial cellular damage in ischemic and reperfused pig hearts: Assessment with gated in vivo 31-phosphorus magnetic resonance spectroscopy and electron microscopy" @default.
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• W2017912576 doi "https://doi.org/10.1016/0022-2828(92)91156-y" @default.
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