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- W2017918734 abstract "Adipose tissue is a major source of energy for the human body. It is also a source of major adipocytokines adiponectin and leptin. Insulin resistance is a condition in which insulin action is impaired in adipose tissue and is more strongly linked to intra-abdominal fat than to fat in other depots. The expression of adiponectin decreases with increase in the adiposity. Adiponectin mediates insulin-sensitizing effect through binding to its receptors AdipoR1 and AdipoR2, leading to activation of adenosine monophosphate dependent kinase (AMPK), PPAR-α, and presumably other yet-unknown signalling pathways. Weight loss significantly elevates plasma adiponectin levels. Reduction of adiponectin has been associated with insulin resistance, dyslipidemia, and atherosclerosis in humans. The other major adipokine is leptin. Leptin levels increase in obesity and subcutaneous fat has been a major determinant of circulating leptin levels. The leptin signal is transmitted by the Janus kinase, signal transducer and activator of transcription ((JAK-STAT) pathway. The net action of leptin is to inhibit appetite, stimulate thermogenesis, enhance fatty acid oxidation, decrease glucose, and reduce body weight and fat." @default.
- W2017918734 created "2016-06-24" @default.
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- W2017918734 creator A5055830989 @default.
- W2017918734 creator A5060768702 @default.
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- W2017918734 date "2013-02-01" @default.
- W2017918734 modified "2023-10-13" @default.
- W2017918734 title "Role of leptin and adiponectin in insulin resistance" @default.
- W2017918734 cites W1524321743 @default.
- W2017918734 cites W1587875569 @default.
- W2017918734 cites W1590709474 @default.
- W2017918734 cites W1675830194 @default.
- W2017918734 cites W1970205234 @default.
- W2017918734 cites W1971452427 @default.
- W2017918734 cites W1981261500 @default.
- W2017918734 cites W1983128420 @default.
- W2017918734 cites W1984746377 @default.
- W2017918734 cites W1988250078 @default.
- W2017918734 cites W1993722516 @default.
- W2017918734 cites W1996713062 @default.
- W2017918734 cites W1996958355 @default.
- W2017918734 cites W1997978122 @default.
- W2017918734 cites W1998493448 @default.
- W2017918734 cites W2001727439 @default.
- W2017918734 cites W2009818179 @default.
- W2017918734 cites W2013715040 @default.
- W2017918734 cites W2014887370 @default.
- W2017918734 cites W2018937378 @default.
- W2017918734 cites W2024729268 @default.
- W2017918734 cites W2024734221 @default.
- W2017918734 cites W2025846514 @default.
- W2017918734 cites W2028336115 @default.
- W2017918734 cites W2042621509 @default.
- W2017918734 cites W2042706232 @default.
- W2017918734 cites W2042893069 @default.
- W2017918734 cites W2045182106 @default.
- W2017918734 cites W2049965571 @default.
- W2017918734 cites W2050900577 @default.
- W2017918734 cites W2052146004 @default.
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- W2017918734 cites W2061128822 @default.
- W2017918734 cites W2062162775 @default.
- W2017918734 cites W2063439586 @default.
- W2017918734 cites W2065697164 @default.
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- W2017918734 cites W2074303577 @default.
- W2017918734 cites W2077738040 @default.
- W2017918734 cites W2087482176 @default.
- W2017918734 cites W2090399640 @default.
- W2017918734 cites W2091087465 @default.
- W2017918734 cites W2091759162 @default.
- W2017918734 cites W2095022880 @default.
- W2017918734 cites W2101680331 @default.
- W2017918734 cites W2102677290 @default.
- W2017918734 cites W2107940713 @default.
- W2017918734 cites W2108931588 @default.
- W2017918734 cites W2109742508 @default.
- W2017918734 cites W2117260572 @default.
- W2017918734 cites W2118491713 @default.
- W2017918734 cites W2118723490 @default.
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- W2017918734 cites W2126101166 @default.
- W2017918734 cites W2126521413 @default.
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- W2017918734 cites W2129316761 @default.
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- W2017918734 cites W2138013274 @default.
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- W2017918734 cites W2148874225 @default.
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- W2017918734 cites W2152687976 @default.
- W2017918734 cites W2159563400 @default.
- W2017918734 cites W2159829835 @default.
- W2017918734 cites W2160589226 @default.
- W2017918734 cites W2162896364 @default.
- W2017918734 cites W2164853297 @default.
- W2017918734 cites W2168761911 @default.
- W2017918734 cites W2169799551 @default.
- W2017918734 cites W2182150538 @default.
- W2017918734 cites W2262880677 @default.
- W2017918734 cites W2334337188 @default.
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- W2017918734 cites W4233349015 @default.
- W2017918734 cites W4238663920 @default.
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- W2017918734 doi "https://doi.org/10.1016/j.cca.2012.12.007" @default.
- W2017918734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23266767" @default.
- W2017918734 hasPublicationYear "2013" @default.
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