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• W2017922072 abstract "To assess the efficacy of omeprazole in treating irritable infants with gastroesophageal reflux and/or esophagitis.Irritable infants (n=30) 3 to 12 months of age met the entry criteria of esophageal acid exposure >5% (n=22) and/or abnormal esophageal histology (n=15). They completed a 4-week, randomized, double-blind, placebo-controlled crossover trial of omeprazole. Cry/fuss diary (minutes/24 hours) and a visual analogue scale of infant irritability as judged by parental impression were obtained at baseline and the end of each 2-week treatment period.The reflux index fell significantly during omeprazole treatment compared with placebo (-8.9%+/-5.6%, -1.9%+/-2.0%, P<.001). Cry/fuss time decreased from baseline (267+/-119), regardless of treatment sequence (period 1, 203+/-99, P<.04; period 2, 188+/-121, P<.008). Visual analogue score decreased from baseline to period 2 (6.8+/-1.6, 4.8+/-2.9, P=.008). There was no significant difference for both outcome measures while taking either omeprazole or placebo.Compared with placebo, omeprazole significantly reduced esophageal acid exposure but not irritability. Irritability improved with time, regardless of treatment." @default.
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• W2017922072 date "2003-08-01" @default.
• W2017922072 modified "2023-10-18" @default.
• W2017922072 title "Double-blind placebo-controlled trial of omeprazole in irritable infants with gastroesophageal reflux" @default.
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• W2017922072 doi "https://doi.org/10.1067/s0022-3476(03)00207-5" @default.
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