Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017922445> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2017922445 endingPage "13680" @default.
- W2017922445 startingPage "13670" @default.
- W2017922445 abstract "We have used adenovirus-mediated gene transfer in apoA-I-deficient (A-I-/-) mice to probe the in vivo assembly and metabolism of HDL using apoA-I variants, focusing primarily on the role of the C-terminal 32 amino acids (helices 9−10). Lipid, lipoprotein, and apoA-I analyses showed that plasma levels of apoA-I and HDL of the mutants were 40−88% lower than that of wild type (WT) human apoA-I despite comparable levels of expression in the liver. WT apoA-I and mutant 1 (P165A, E172A) formed spherical particles with the size and density of HDL2 and HDL3. Mutant 2 (E234A, E235A, K238A, K239A) generated spherical particles with density between HDL2 and HDL3. Mutant 3 (L211V, L214V, L218V, L219V) and mutant 4 (L222K, F225K, F229K), which have substitutions of hydrophobic residues in the C-terminus, generated discoidal HDL particles indicating a defect in their conversion to mature spherical HDL. Significant amounts of mutant 4 and mutant 5 (truncated at residue 219) were found in the lipid poor fractions after ultracentrifugation of the plasma (18 and 35%, respectively, of total apoA-I). These findings suggest that hydrophobic residues in and/or between helices 9 and 10 are important for the maturation of HDL in vivo." @default.
- W2017922445 created "2016-06-24" @default.
- W2017922445 creator A5021568228 @default.
- W2017922445 creator A5029109140 @default.
- W2017922445 creator A5029540660 @default.
- W2017922445 creator A5034055537 @default.
- W2017922445 creator A5053102206 @default.
- W2017922445 creator A5059608163 @default.
- W2017922445 creator A5074485792 @default.
- W2017922445 creator A5084708680 @default.
- W2017922445 creator A5088977376 @default.
- W2017922445 date "2001-10-12" @default.
- W2017922445 modified "2023-09-27" @default.
- W2017922445 title "In Vivo Studies of HDL Assembly and Metabolism Using Adenovirus-Mediated Transfer of ApoA-I Mutants in ApoA-I-Deficient Mice" @default.
- W2017922445 doi "https://doi.org/10.1021/bi011451e" @default.
- W2017922445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11695916" @default.
- W2017922445 hasPublicationYear "2001" @default.
- W2017922445 type Work @default.
- W2017922445 sameAs 2017922445 @default.
- W2017922445 citedByCount "17" @default.
- W2017922445 countsByYear W20179224452014 @default.
- W2017922445 countsByYear W20179224452017 @default.
- W2017922445 crossrefType "journal-article" @default.
- W2017922445 hasAuthorship W2017922445A5021568228 @default.
- W2017922445 hasAuthorship W2017922445A5029109140 @default.
- W2017922445 hasAuthorship W2017922445A5029540660 @default.
- W2017922445 hasAuthorship W2017922445A5034055537 @default.
- W2017922445 hasAuthorship W2017922445A5053102206 @default.
- W2017922445 hasAuthorship W2017922445A5059608163 @default.
- W2017922445 hasAuthorship W2017922445A5074485792 @default.
- W2017922445 hasAuthorship W2017922445A5084708680 @default.
- W2017922445 hasAuthorship W2017922445A5088977376 @default.
- W2017922445 hasConcept C104317684 @default.
- W2017922445 hasConcept C143065580 @default.
- W2017922445 hasConcept C153911025 @default.
- W2017922445 hasConcept C185592680 @default.
- W2017922445 hasConcept C207001950 @default.
- W2017922445 hasConcept C2778163477 @default.
- W2017922445 hasConcept C2780072125 @default.
- W2017922445 hasConcept C4733338 @default.
- W2017922445 hasConcept C54355233 @default.
- W2017922445 hasConcept C54689828 @default.
- W2017922445 hasConcept C55493867 @default.
- W2017922445 hasConcept C86803240 @default.
- W2017922445 hasConceptScore W2017922445C104317684 @default.
- W2017922445 hasConceptScore W2017922445C143065580 @default.
- W2017922445 hasConceptScore W2017922445C153911025 @default.
- W2017922445 hasConceptScore W2017922445C185592680 @default.
- W2017922445 hasConceptScore W2017922445C207001950 @default.
- W2017922445 hasConceptScore W2017922445C2778163477 @default.
- W2017922445 hasConceptScore W2017922445C2780072125 @default.
- W2017922445 hasConceptScore W2017922445C4733338 @default.
- W2017922445 hasConceptScore W2017922445C54355233 @default.
- W2017922445 hasConceptScore W2017922445C54689828 @default.
- W2017922445 hasConceptScore W2017922445C55493867 @default.
- W2017922445 hasConceptScore W2017922445C86803240 @default.
- W2017922445 hasIssue "45" @default.
- W2017922445 hasLocation W20179224451 @default.
- W2017922445 hasLocation W20179224452 @default.
- W2017922445 hasOpenAccess W2017922445 @default.
- W2017922445 hasPrimaryLocation W20179224451 @default.
- W2017922445 hasRelatedWork W1519740704 @default.
- W2017922445 hasRelatedWork W1991147293 @default.
- W2017922445 hasRelatedWork W2002321530 @default.
- W2017922445 hasRelatedWork W2005980797 @default.
- W2017922445 hasRelatedWork W2052438487 @default.
- W2017922445 hasRelatedWork W2080842819 @default.
- W2017922445 hasRelatedWork W2381006689 @default.
- W2017922445 hasRelatedWork W2605798172 @default.
- W2017922445 hasRelatedWork W3029457655 @default.
- W2017922445 hasRelatedWork W2119228986 @default.
- W2017922445 hasVolume "40" @default.
- W2017922445 isParatext "false" @default.
- W2017922445 isRetracted "false" @default.
- W2017922445 magId "2017922445" @default.
- W2017922445 workType "article" @default.