FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017922673> ?p ?o ?g. }

• W2017922673 endingPage "823" @default.
• W2017922673 startingPage "812" @default.
• W2017922673 abstract "Circadian rhythms are endogenous cycles with periods close to, but not exactly equal to, 24 h. In mammals, circadian rhythms are generated in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as several peripheral cell types, such as fibroblasts. Protein kinases are key regulators of the circadian molecular machinery. We investigated the role of the c-Jun N-terminal kinases (JNK), which belong to the mitogen-activated protein kinases family, in the regulation of circadian rhythms. In rat-1 fibroblasts, the p46 kDa, but not the p54 kDa, isoforms of JNK expressed circadian rhythms in phosphorylation. The JNK-inhibitor SP600125 dose-dependently extended the period of Period1-luciferase rhythms in rat-1 fibroblasts from 24.23±0.17–31.48±0.07 h. This treatment also dose-dependently delayed the onset of the bioluminescence rhythms. The effects of SP600125 on explant cultures from Period1-luciferase transgenic mice and Period2Luciferase knockin mice appeared tissue-specific. SP600125 lengthened the period in SCN, pineal gland, and lung explants in Period1-luciferase and Period2Luciferase mice. However, in the kidneys circadian rhythms were abolished in Period1-luciferase, while circadian rhythms were not affected by SP600125 treatment in Period2Luciferase mice. Valproic acid, already known to affect period length, enhanced JNK phosphorylation and, as predicted, shortened the period of the Period1-bioluminescence rhythms in rat-1 fibroblasts. In conclusion, our results showed that SP600125 treatment, as well as valproic acid, alters JNK phosphorylation levels, and modulates the period length in various tissues. We conclude that JNK phosphorylation levels may help to set the period length of mammalian circadian rhythms." @default.
• W2017922673 created "2016-06-24" @default.
• W2017922673 creator A5003484723 @default.
• W2017922673 creator A5011827857 @default.
• W2017922673 creator A5013569947 @default.
• W2017922673 creator A5035753059 @default.
• W2017922673 creator A5054396104 @default.
• W2017922673 date "2007-03-01" @default.
• W2017922673 modified "2023-10-01" @default.
• W2017922673 title "c-Jun N-terminal kinase inhibitor SP600125 modulates the period of mammalian circadian rhythms" @default.
• W2017922673 cites W1484949748 @default.
• W2017922673 cites W150521681 @default.
• W2017922673 cites W1572174728 @default.
• W2017922673 cites W1848906362 @default.
• W2017922673 cites W1920788567 @default.
• W2017922673 cites W1975559445 @default.
• W2017922673 cites W1978984359 @default.
• W2017922673 cites W1982469223 @default.
• W2017922673 cites W1984903682 @default.
• W2017922673 cites W1989460808 @default.
• W2017922673 cites W1990065094 @default.
• W2017922673 cites W1995230392 @default.
• W2017922673 cites W2000855275 @default.
• W2017922673 cites W2003013566 @default.
• W2017922673 cites W2011089118 @default.
• W2017922673 cites W2011588737 @default.
• W2017922673 cites W2014082672 @default.
• W2017922673 cites W2014313900 @default.
• W2017922673 cites W2017712066 @default.
• W2017922673 cites W2035571475 @default.
• W2017922673 cites W2035809873 @default.
• W2017922673 cites W2040532363 @default.
• W2017922673 cites W2040617029 @default.
• W2017922673 cites W2048120611 @default.
• W2017922673 cites W2051369768 @default.
• W2017922673 cites W2054895739 @default.
• W2017922673 cites W2056324134 @default.
• W2017922673 cites W2058563938 @default.
• W2017922673 cites W2060140960 @default.
• W2017922673 cites W2060931179 @default.
• W2017922673 cites W2064345264 @default.
• W2017922673 cites W2066821552 @default.
• W2017922673 cites W2072942401 @default.
• W2017922673 cites W2074120747 @default.
• W2017922673 cites W2074702672 @default.
• W2017922673 cites W2075152619 @default.
• W2017922673 cites W2076042488 @default.
• W2017922673 cites W2080963419 @default.
• W2017922673 cites W2082697543 @default.
• W2017922673 cites W2083118618 @default.
• W2017922673 cites W2086330310 @default.
• W2017922673 cites W2092521700 @default.
• W2017922673 cites W2096931514 @default.
• W2017922673 cites W2100416578 @default.
• W2017922673 cites W2112045765 @default.
• W2017922673 cites W2115980405 @default.
• W2017922673 cites W2121075147 @default.
• W2017922673 cites W2126357344 @default.
• W2017922673 cites W2139844513 @default.
• W2017922673 cites W2141151090 @default.
• W2017922673 cites W2142478420 @default.
• W2017922673 cites W2146586614 @default.
• W2017922673 cites W2152043154 @default.
• W2017922673 cites W2153693153 @default.
• W2017922673 cites W2159825471 @default.
• W2017922673 cites W2160091872 @default.
• W2017922673 cites W2161579926 @default.
• W2017922673 cites W2171236970 @default.
• W2017922673 cites W2414529633 @default.
• W2017922673 cites W2616499466 @default.
• W2017922673 cites W314393173 @default.
• W2017922673 cites W4362196385 @default.
• W2017922673 doi "https://doi.org/10.1016/j.neuroscience.2006.12.037" @default.
• W2017922673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2238338" @default.
• W2017922673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17270352" @default.
• W2017922673 hasPublicationYear "2007" @default.
• W2017922673 type Work @default.
• W2017922673 sameAs 2017922673 @default.
• W2017922673 citedByCount "36" @default.
• W2017922673 countsByYear W20179226732012 @default.
• W2017922673 countsByYear W20179226732013 @default.
• W2017922673 countsByYear W20179226732014 @default.
• W2017922673 countsByYear W20179226732015 @default.
• W2017922673 countsByYear W20179226732016 @default.
• W2017922673 countsByYear W20179226732017 @default.
• W2017922673 countsByYear W20179226732018 @default.
• W2017922673 countsByYear W20179226732019 @default.
• W2017922673 countsByYear W20179226732020 @default.
• W2017922673 countsByYear W20179226732023 @default.
• W2017922673 crossrefType "journal-article" @default.
• W2017922673 hasAuthorship W2017922673A5003484723 @default.
• W2017922673 hasAuthorship W2017922673A5011827857 @default.
• W2017922673 hasAuthorship W2017922673A5013569947 @default.
• W2017922673 hasAuthorship W2017922673A5035753059 @default.
• W2017922673 hasAuthorship W2017922673A5054396104 @default.
• W2017922673 hasBestOaLocation W20179226732 @default.
• W2017922673 hasConcept C111335760 @default.
• W2017922673 hasConcept C11960822 @default.

• next