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• W2017924401 abstract "Most recent advances in nanomaterials fabrication have given access to complex materials such as SiO 2 -Na 2 O-CaO-P 2 O 5 bioactive glasses in the form of amorphous nanoparticles of 20- to 60-nm size. The clinically interesting antimicrobial properties of commercially available, micron-sized bioactive glass 45S5 have been attributed to the continuous liberation of alkaline species during application. Here, we tested the hypothesis that, based on its more than ten-fold higher specific surface area, nanometric bioactive glass releases more alkaline species, and consequently displays a stronger antimicrobial effect, than the currently applied micron-sized material. Ionic dissolution profiles were monitored in simulated body fluid. Antimicrobial efficacy was assessed against clinical isolates of enterococci from persisting root canal infections. The shift from micron- to nano-sized treatment materials afforded a ten-fold increase in silica release and solution pH elevation by more than three units. Furthermore, the killing efficacy was substantially higher with the new material against all tested strains." @default.
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• W2017924401 date "2007-08-01" @default.
• W2017924401 modified "2023-10-17" @default.
• W2017924401 title "Antimicrobial Effect of Nanometric Bioactive Glass 45S5" @default.
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• W2017924401 doi "https://doi.org/10.1177/154405910708600813" @default.
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