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• W2017926917 abstract "Summary Context Autoimmune thyroid diseases ( AITDs ), including Graves’ disease ( GD ) and Hashimoto's thyroiditis ( HT ), are the most common autoimmune diseases. Micro RNA s (mi RNA s) are small noncoding RNA s, which can play pivotal roles in immune functions and development of autoimmunity. Recently, it has been recognized that identification of circulating mi RNA s can provide important and novel information regarding disease pathogenesis and clinical condition. However, the role circulating mi RNA s in AITD has not yet been described. Objective The aim of this study was to characterize the different circulating levels of mi RNA in patients with AITD . Design and methods Sixty‐four participants who met the criteria for HT or GD and healthy subjects were recruited. Microarrays were used to analyse the expression patterns of mi RNA in serum obtained from patients with HT and GD and healthy subjects. After analysing the microarray data, four interesting mi RNAs (miR‐16, miR‐22, miR‐375 and miR‐451) were selected and validated by quantitative real‐time PCR . Results Several mi RNA s were observed to be differently expressed in serum from patients with AITD compared with healthy subjects by microarray analysis. Further analysis consistently showed that serum levels of miR‐22, miR‐375 and miR‐451 were increased in patients with HT . On the other hand, the serum levels of miR‐16, miR‐22, miR‐375 and miR‐451 were increased in patients with GD compared with healthy subjects. Conclusions We revealed that different levels of serum mi RNA s were associated with GD and HT , which may play a role in the pathogenesis of these diseases." @default.
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• W2017926917 date "2014-03-19" @default.
• W2017926917 modified "2023-10-04" @default.
• W2017926917 title "Circulating microRNAs in autoimmune thyroid diseases" @default.
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• W2017926917 doi "https://doi.org/10.1111/cen.12432" @default.
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