FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017935893> ?p ?o ?g. }

• W2017935893 endingPage "181" @default.
• W2017935893 startingPage "174" @default.
• W2017935893 abstract "The last decade has seen changes in the epidemiology of mucosal squamous cell carcinomas of the head and neck (HNSCCs), with increasing numbers of cases attributable to human papillomavirus (HPV) infection. We sought to determine the prevalence of HPV and p16INK4a expression in Australian HNSCC patients and to identify predictors of HPV-positivity. We recruited 248 HNSCC patients with histologically confirmed primary SCC of the oropharynx, oral cavity, hypopharynx or larynx diagnosed between 2004 and 2010. All patients completed a questionnaire. Clinical data were abstracted from medical records. HPV presence in paraffin-embedded tumours was determined by PCR, and expression of p16INK4a, p21WAF1, p53, pRB, cyclin D1, and Ki67 by immunohistochemistry. Fifty (20%) patients were HPV-positive, 63 (28%) overexpressed p16INK4a, and 44 (19%) were positive for HPV and p16INK4a (high concordance between HPV-positivity and p16INK4a status, κ = 0.72). HPV-16 was most common (84%), followed by HPV-18 (10%), HPV-33 (4%) and HPV-69 (2%). HPV and p16INK4a prevalence was highest for SCCs of the oropharynx, followed by hypopharynx, larynx and oral cavity (HPV and p16INK4a p < 0.0001). HPV prevalence and p16INK4a-overexpression were significantly higher in younger than older patients (HPV p = 0.001; p16 INK4a p = 0.003). Heavy smokers had lower HPV prevalence than non- or moderate smokers (p = 0.017). Gender and alcohol consumption were not associated with HPV or p16INK4a status. HPV-positive tumours had significantly lower cyclin D1 and higher p21WAF1 expression than HPV-negative tumours. HPV prevalence and p16INK4a-overexpression were highest in oropharyngeal tumours, younger patients, and non-smokers." @default.
• W2017935893 created "2016-06-24" @default.
• W2017935893 creator A5005373482 @default.
• W2017935893 creator A5027765428 @default.
• W2017935893 creator A5046450863 @default.
• W2017935893 creator A5047485758 @default.
• W2017935893 creator A5055233024 @default.
• W2017935893 creator A5055591728 @default.
• W2017935893 creator A5071421046 @default.
• W2017935893 creator A5077862296 @default.
• W2017935893 date "2015-04-01" @default.
• W2017935893 modified "2023-10-14" @default.
• W2017935893 title "Human papillomavirus status and p16INK4A expression in patients with mucosal squamous cell carcinoma of the head and neck in Queensland, Australia" @default.
• W2017935893 cites W1831319429 @default.
• W2017935893 cites W190015672 @default.
• W2017935893 cites W1941278354 @default.
• W2017935893 cites W1968479788 @default.
• W2017935893 cites W1978572584 @default.
• W2017935893 cites W1981989535 @default.
• W2017935893 cites W1990956554 @default.
• W2017935893 cites W1996712834 @default.
• W2017935893 cites W2020830322 @default.
• W2017935893 cites W2029952336 @default.
• W2017935893 cites W2039382131 @default.
• W2017935893 cites W2039384336 @default.
• W2017935893 cites W2041949509 @default.
• W2017935893 cites W2048878411 @default.
• W2017935893 cites W2056023468 @default.
• W2017935893 cites W2079193656 @default.
• W2017935893 cites W2081183900 @default.
• W2017935893 cites W2088971686 @default.
• W2017935893 cites W2093106099 @default.
• W2017935893 cites W2097978020 @default.
• W2017935893 cites W2099281944 @default.
• W2017935893 cites W2109419578 @default.
• W2017935893 cites W2112028495 @default.
• W2017935893 cites W2114049909 @default.
• W2017935893 cites W2125806459 @default.
• W2017935893 cites W2128428788 @default.
• W2017935893 cites W2129106917 @default.
• W2017935893 cites W2131597845 @default.
• W2017935893 cites W2133183695 @default.
• W2017935893 cites W2141274038 @default.
• W2017935893 cites W2145236786 @default.
• W2017935893 cites W2149166037 @default.
• W2017935893 cites W2152408151 @default.
• W2017935893 cites W2170178908 @default.
• W2017935893 cites W2170409331 @default.
• W2017935893 cites W2342166036 @default.
• W2017935893 doi "https://doi.org/10.1016/j.canep.2015.01.010" @default.
• W2017935893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25677091" @default.
• W2017935893 hasPublicationYear "2015" @default.
• W2017935893 type Work @default.
• W2017935893 sameAs 2017935893 @default.
• W2017935893 citedByCount "41" @default.
• W2017935893 countsByYear W20179358932015 @default.
• W2017935893 countsByYear W20179358932016 @default.
• W2017935893 countsByYear W20179358932017 @default.
• W2017935893 countsByYear W20179358932018 @default.
• W2017935893 countsByYear W20179358932019 @default.
• W2017935893 countsByYear W20179358932020 @default.
• W2017935893 countsByYear W20179358932021 @default.
• W2017935893 countsByYear W20179358932022 @default.
• W2017935893 countsByYear W20179358932023 @default.
• W2017935893 crossrefType "journal-article" @default.
• W2017935893 hasAuthorship W2017935893A5005373482 @default.
• W2017935893 hasAuthorship W2017935893A5027765428 @default.
• W2017935893 hasAuthorship W2017935893A5046450863 @default.
• W2017935893 hasAuthorship W2017935893A5047485758 @default.
• W2017935893 hasAuthorship W2017935893A5055233024 @default.
• W2017935893 hasAuthorship W2017935893A5055591728 @default.
• W2017935893 hasAuthorship W2017935893A5071421046 @default.
• W2017935893 hasAuthorship W2017935893A5077862296 @default.
• W2017935893 hasConcept C107130276 @default.
• W2017935893 hasConcept C121608353 @default.
• W2017935893 hasConcept C126322002 @default.
• W2017935893 hasConcept C141071460 @default.
• W2017935893 hasConcept C143998085 @default.
• W2017935893 hasConcept C160798450 @default.
• W2017935893 hasConcept C199835354 @default.
• W2017935893 hasConcept C204232928 @default.
• W2017935893 hasConcept C2776530083 @default.
• W2017935893 hasConcept C2776833033 @default.
• W2017935893 hasConcept C2778220009 @default.
• W2017935893 hasConcept C2778580637 @default.
• W2017935893 hasConcept C2780474809 @default.
• W2017935893 hasConcept C29537977 @default.
• W2017935893 hasConcept C2994532551 @default.
• W2017935893 hasConcept C71924100 @default.
• W2017935893 hasConceptScore W2017935893C107130276 @default.
• W2017935893 hasConceptScore W2017935893C121608353 @default.
• W2017935893 hasConceptScore W2017935893C126322002 @default.
• W2017935893 hasConceptScore W2017935893C141071460 @default.
• W2017935893 hasConceptScore W2017935893C143998085 @default.
• W2017935893 hasConceptScore W2017935893C160798450 @default.
• W2017935893 hasConceptScore W2017935893C199835354 @default.
• W2017935893 hasConceptScore W2017935893C204232928 @default.
• W2017935893 hasConceptScore W2017935893C2776530083 @default.

• next