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• W2017941012 abstract "Validar un modelo experimental de derivación biliopancreática de Larrad (DBPL) y analizar las modificaciones ponderales y mortalidad en los animales operados alimentados con dieta estándar no suplementada. Se utilizan 6 animales control y 10 operados, machos de la cepa Wistar. Se interviene al grupo de ratas operado con una adaptación de la técnica de Larrad en humanos: gastrectomía subcardial, canal biliopancreático corto creado a 5 cm del ángulo de Treitz y canal común a 5 cm de la válvula ileocecal. Tras un período de recuperación de 7 días las ratas se alimentan ad libitum con una dieta estándar no suplementada (sin proteínas, minerales o vitaminas), y se analiza el porcentaje de peso ganado o perdido. Los animales control ganan peso progresivamente desde un 13,1 ± 2,4% en el día 7 hasta un 58 ± 9,2% en el día 63, momento en el que se los sacrificaba. Tras la DBPL la mortalidad es del 50% a los 25 ± 17,5(rango, 14-56) días, sin diferencias significativas en el porcentaje de peso perdido entre los animales que sobrevivieron (–38,9 ± 14,2%) y los que fallecieron (–29 ± 5,6%; p = 0,192). El 80% de los animales que sobrevivieron perdieron peso progresivamente hasta alcanzar la máxima pérdida entre los 63 (–42,3 ± 8%) y 70 (–44,1 ± 9,7%) días. Un 20% de las ratas supervivientes perdieron peso hasta el día 35 y posteriormente recuperaron hasta un 7% el día del sacrificio (día 147). El modelo experimental de DBPL es técnicamente factible. La mortalidad y el porcentaje de peso perdido no se encuentran directamente relacionados. El mecanismo de adaptación intestinal justificaría la recuperación de peso de los animales operados. To validate the experimental model of Larrad-biliopancreatic diversion (LBPD) and to analyze weight gain and mortality in rats fed with non– supplemented diets. Control (6) and experimental (10) male Wistar rats were used. The experimental group was operated on using the human LBPD adapted for rats: Subcardial gastrectomy, a short biliopancreatic channel created at 5 cm from Treitz angle and common channel at 5 cm from ileocecal valve. After surgery recovery (7 days) the rats were fed ab libitum with a standard non-supplemented diet (without proteins, minerals or vitamins). Percentage of weight lost or gained up to the end of the experiment was analyzed. The control animals gained weight progressively from 13.1 ± 2.4% at day 7 to 58 ± 9.2% at day 63, when the animals were sacrificed. After LBPD, mortality was 50% at day 25 ± 17.5(range, 14-56), no significant differences in the percentage of weight lost being found between surviving (–38.9 ± 14.2%) and non-surviving rats (–29 ± 5.6%; p = 0.192). Of the surviving animals, 80% progressively lost weight reaching a maximum loss between day 63 (–42.3 ± 8%) and 70 (–44.1 ± 9.7%), and 20% lost weight until day 35 and gained over 7% of body weight until sacrifice (day 147). An experimental model of LBPD in rats is technically feasible. Both mortality and percentage weight loss are not directly related. The bowel adaptation mechanism could mediate the percentage of weight regain in operated rats." @default.
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• W2017941012 date "2008-02-01" @default.
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• W2017941012 title "Derivación biliopancreática de Larrad. Descripción de un modelo experimental en la rata" @default.
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• W2017941012 doi "https://doi.org/10.1016/s0009-739x(08)70512-8" @default.
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