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- W2017946641 abstract "Cell lysates of the human monoblastic leukemia cell line, THP-1, have procoagulant activity (PCA) that is Ca++-dependent and not demonstrable in either Factor VII-, or Factor X-deficient plasma. The PCA of THP-1 cells was enhanced by human recombinant tumor necrosis factor- α (TNF- α) up to five fold. There was a dose-dependent increase in PCA when THP-1 cells were cultured with concentrations of TNF-α, up to 10 U/ml. PCA of cell lysates or whole cell preparations was measured in comparison to a rabbit brain thromboplastin standard. The effect of TNF-α was enhanced by recombinant human interferon-γ (IFN-γ). Cycloheximide inhibited the induction of PCA by THP-1 cells, which shows that the protein synthesis is essential to mediate the effect of TNF-α. THP-1 cells and U937 cells bound 125I-labeled TNF specifically. The numbers of receptors per cell were found to be 1,890 and 1,550 for THP-1 and U937 cells, respectively. Other lymphoid and myeloblastic leukemia cell lines examined did not have TNF receptors, indicating that the effect of TNF-α is mediated by the receptors on the cell surface." @default.
- W2017946641 created "2016-06-24" @default.
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- W2017946641 date "1989-10-01" @default.
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- W2017946641 title "Induction of tissue factor-like activity of human monoblastic leukemia cell line by tumor necrosis factor-alpha" @default.
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- W2017946641 doi "https://doi.org/10.1016/0049-3848(89)90162-x" @default.
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