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• W2017950489 abstract "The priming of an antibacterial response requires the uptake and presentation of bacterial antigens by dendritic cells. Busch and colleagues describe a new platelet-dependent mechanism for shuttling bacteria to dendritic cells. The acquisition of pathogen-derived antigen by dendritic cells (DCs) is a key event in the generation of cytotoxic CD8+ T cell responses. In mice, the intracellular bacterium Listeria monocytogenes is directed from the blood to splenic CD8α+ DCs. We report that L. monocytogenes rapidly associated with platelets in the bloodstream in a manner dependent on GPIb and complement C3. Platelet association targeted a small but immunologically important portion of L. monocytogenes to splenic CD8α+ DCs, diverting bacteria from swift clearance by other, less immunogenic phagocytes. Thus, an effective balance is established between maintaining sterility of the circulation and induction of antibacterial immunity by DCs. Other Gram-positive bacteria also were rapidly tagged by platelets, revealing a broadly active shuttling mechanism for systemic bacteria." @default.
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• W2017950489 date "2011-10-30" @default.
• W2017950489 modified "2023-10-01" @default.
• W2017950489 title "A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3" @default.
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• W2017950489 doi "https://doi.org/10.1038/ni.2140" @default.
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