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- W2017952407 abstract "Background: Islet transplantation is one of regimens supplying the deficient insulin in diabetes patients, but the effects of islet grafts on the changes of endogenous β-cells are not clear. In the present study, we examined the changes of endogenous β-cell mass after islet transplantation in partially pancreatectomized mice. Methods: Balb/c mice were 70% pancreatectomized, transplanted with syngeneic islets (group IV), and were compared with pancreatectomized mice treated with insulin (group III) or no insulin (group II). Blood glucose levels and body weight were monitored. Remnant pancreas was obtained at 6 or 10 days after pancreatectomy, and immunohistochemical staining was done for the evaluation of β-cell mass changes.Results: Hyperglycemia and weight loss were induced after pancreatectomy. After islet transplantation or insulin treatment, blood glucose levels recovered to normal, and body weight started to increase. Plasma insulin levels were higher and β-cell mass was larger in group IV than in group II (P" @default.
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- W2017952407 date "2007-01-01" @default.
- W2017952407 modified "2023-09-27" @default.
- W2017952407 title "Effects of Islet Transplantation on Endogenous β-cell Regeneration after Partial Pancreatectomy in Rodents" @default.
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- W2017952407 doi "https://doi.org/10.4093/jkda.2007.31.2.113" @default.
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