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• W2017959309 abstract "We report the first molecular characterization of Vx regions of the main human autoantibodies occurring during rheumatoid arthritis, the polyclonal rheumatoid factors. Using two sets of polymerase chain reactions in order to amplify the cDNA derived from both peripheral blood and synovial fluid rheumatoid factor-secreting cells, nucleotide analysis of the VxIII family usage shows the following: (a) at least three different VxIII genes are used to encode polyclonal rheumatoid factors in a single patient, (b) each one of these genes seems more or less somatically mutated (from 1 to 14 mutations), (c) the mutation process preferentially affects the complementarity determining regions suggesting a selective pressure of antigen and (d) there is no clear difference between the mutation rates affecting the synovial fluid and peripheral blood rheumatoid factor-secreting cells. These results are able to explain some of the known idiotypic differences between monoclonal and polyclonal rheumatoid factors in humans. They also provide evidence that polyclonal autoantibodies arising during an autoimmune disease can be the products of multiple somatically mutated genes and suggest that this process is antigen driven, whether this antigen is the Fc piece of IgG or another unknown antigen." @default.
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• W2017959309 date "1991-05-01" @default.
• W2017959309 modified "2023-09-25" @default.
• W2017959309 title "Molecular analysis of VxIII variable regions of polyclonal rheumatoid factors during rheumatoid arthritis" @default.
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• W2017959309 doi "https://doi.org/10.1002/eji.1830210519" @default.
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