FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W201797715> ?p ?o ?g. }

• W201797715 abstract "BackgroundAnthropogenic air pollution is a global health problem estimated to contribute to millions of premature deaths. Exposure to biomass smoke is common due to varying sources, such as wildfires, indoor cooking over open fires, and residential heating from wood stoves. In urban environments transportation and industry rely heavily on the combustion of fossil fuels yet environmental policies increasingly support a shift to renewable fuels such as biodiesel. It has not been investigated how either wood smoke or biodiesel exhaust affect human health in general or the cardiovascular system in particular. We hypothesized that wood smoke exposure would induce acute cardiovascular impairment via similar underlying mechanisms as have been established for petrodiesel exhaust exposure. We also hypothesized that replacing petrodiesel with biodiesel, as a blend or pure biodiesel, would generate an exhaust profile with a less harmful effect on the cardiovascular system than petrodiesel exhaust.MethodsIn four separate studies healthy non-smoking subjects were exposed to different air pollutants in controlled exposure chambers followed by clinical investigations of the cardiovascular system. All studies were performed as randomized controlled trials in a crossover fashion with each individual acting as her own control. In study I healthy volunteers were exposed to wood smoke at a target concentration of particulate matter (PM) 300 µg/m3 for three hours followed by measures of blood pressure, heart rate variability and central arterial stiffness. In study II subjects were exposed to wood smoke at a target concentration of PM 1000 µg/m3 for one hour followed by measures of thrombus formation using the Badimon technique and vasomotor function using forearm venous occlusion plethysmography. In study III subjects were exposed to petrodiesel exhaust and a 30% rapeseed methyl ester (RME30) biodiesel blend for one hour at a target concentration of PM 300 µg/m3. Following exposure, thrombus formation and vasomotor function were assessed as in study II. In study IV subjects were exposed to petrodiesel exhaust at a target concentration of PM 300 μg/m3for one hour and pure rapeseed methyl ester (RME100) exhaust generated at identical running conditions of the engine. Following exposure, thrombus formation and vasomotor function were assessed as in study II and III.ResultsIn study I fourteen subjects (8 males) were exposed to wood smoke at P M 294±36 μg/m3. Compared to filtered air exposure, measures of central arterial stiffness were increased and heart rate variability was decreased following wood smoke exposure. No effect was seen on blood pressure. In study II sixteen males were exposed to wood smoke at PM 899±100 μg/m3. We found no evidence of increased thrombus formation or impaired vasomotor function following wood smoke exposure. In study III sixteen subjects (14 males) were exposed to petrodiesel exhaust (PM 314±27 µg/m3) and RME30 exhaust (PM 309±30 µg/m3). Thrombus formation and vasomotor function were equal following either exposure. In study IV nineteen males were exposed to petrodiesel exhaust (PM 310±34 µg/m3, 1.7±0.3 x105 particles/cm3) and RME100 exhaust (PM 165±16 µg/m3, 2.2±0.1 x105 particles/cm3). As in study III, thrombus formation and vasomotor function were identical following both exposures.ConclusionsWe have for the first time demonstrated that wood smoke exposure can increase central arterial stiffness and decrease heart rate variability in healthy subjects. We did not, however find evidence of increased thrombus formation and impaired vasomotor function following wood smoke exposure at a higher concentration for a shorter time period. We have, for the first time, demonstrated that exhaust from RME biodiesel induced acute adverse cardiovascular effects of increased thrombus formation and impaired vasomotor function in man. These effects are on par with those seen following exposure to petrodiesel exhaust, despite marked physicochemical differences of the exhaust characteristics." @default.
• W201797715 created "2016-06-24" @default.
• W201797715 creator A5004221830 @default.
• W201797715 creator A5015443776 @default.
• W201797715 creator A5017396719 @default.
• W201797715 creator A5030626676 @default.
• W201797715 creator A5035387848 @default.
• W201797715 creator A5044116116 @default.
• W201797715 creator A5047736312 @default.
• W201797715 creator A5051631621 @default.
• W201797715 creator A5065983670 @default.
• W201797715 creator A5068470025 @default.
• W201797715 creator A5068493192 @default.
• W201797715 creator A5069583505 @default.
• W201797715 creator A5074252129 @default.
• W201797715 creator A5078437844 @default.
• W201797715 creator A5083682938 @default.
• W201797715 date "2014-01-01" @default.
• W201797715 modified "2023-10-01" @default.
• W201797715 title "Rapeseed Methyl Ester Biodiesel Exhaust Exposure Causes Vascular Dysfunction in Man" @default.
• W201797715 hasPublicationYear "2014" @default.
• W201797715 type Work @default.
• W201797715 sameAs 201797715 @default.
• W201797715 citedByCount "0" @default.
• W201797715 crossrefType "journal-article" @default.
• W201797715 hasAuthorship W201797715A5004221830 @default.
• W201797715 hasAuthorship W201797715A5015443776 @default.
• W201797715 hasAuthorship W201797715A5017396719 @default.
• W201797715 hasAuthorship W201797715A5030626676 @default.
• W201797715 hasAuthorship W201797715A5035387848 @default.
• W201797715 hasAuthorship W201797715A5044116116 @default.
• W201797715 hasAuthorship W201797715A5047736312 @default.
• W201797715 hasAuthorship W201797715A5051631621 @default.
• W201797715 hasAuthorship W201797715A5065983670 @default.
• W201797715 hasAuthorship W201797715A5068470025 @default.
• W201797715 hasAuthorship W201797715A5068493192 @default.
• W201797715 hasAuthorship W201797715A5069583505 @default.
• W201797715 hasAuthorship W201797715A5074252129 @default.
• W201797715 hasAuthorship W201797715A5078437844 @default.
• W201797715 hasAuthorship W201797715A5083682938 @default.
• W201797715 hasConcept C126322002 @default.
• W201797715 hasConcept C127413603 @default.
• W201797715 hasConcept C138171918 @default.
• W201797715 hasConcept C161790260 @default.
• W201797715 hasConcept C185592680 @default.
• W201797715 hasConcept C18903297 @default.
• W201797715 hasConcept C2775850156 @default.
• W201797715 hasConcept C3432839 @default.
• W201797715 hasConcept C39432304 @default.
• W201797715 hasConcept C52896960 @default.
• W201797715 hasConcept C548081761 @default.
• W201797715 hasConcept C55493867 @default.
• W201797715 hasConcept C559116025 @default.
• W201797715 hasConcept C58874564 @default.
• W201797715 hasConcept C71924100 @default.
• W201797715 hasConcept C84393581 @default.
• W201797715 hasConcept C86803240 @default.
• W201797715 hasConcept C99454951 @default.
• W201797715 hasConceptScore W201797715C126322002 @default.
• W201797715 hasConceptScore W201797715C127413603 @default.
• W201797715 hasConceptScore W201797715C138171918 @default.
• W201797715 hasConceptScore W201797715C161790260 @default.
• W201797715 hasConceptScore W201797715C185592680 @default.
• W201797715 hasConceptScore W201797715C18903297 @default.
• W201797715 hasConceptScore W201797715C2775850156 @default.
• W201797715 hasConceptScore W201797715C3432839 @default.
• W201797715 hasConceptScore W201797715C39432304 @default.
• W201797715 hasConceptScore W201797715C52896960 @default.
• W201797715 hasConceptScore W201797715C548081761 @default.
• W201797715 hasConceptScore W201797715C55493867 @default.
• W201797715 hasConceptScore W201797715C559116025 @default.
• W201797715 hasConceptScore W201797715C58874564 @default.
• W201797715 hasConceptScore W201797715C71924100 @default.
• W201797715 hasConceptScore W201797715C84393581 @default.
• W201797715 hasConceptScore W201797715C86803240 @default.
• W201797715 hasConceptScore W201797715C99454951 @default.
• W201797715 hasLocation W2017977151 @default.
• W201797715 hasOpenAccess W201797715 @default.
• W201797715 hasPrimaryLocation W2017977151 @default.
• W201797715 hasRelatedWork W1849447229 @default.
• W201797715 hasRelatedWork W1923789681 @default.
• W201797715 hasRelatedWork W2005247691 @default.
• W201797715 hasRelatedWork W2016022961 @default.
• W201797715 hasRelatedWork W2033269660 @default.
• W201797715 hasRelatedWork W2066600186 @default.
• W201797715 hasRelatedWork W2109996123 @default.
• W201797715 hasRelatedWork W2133867054 @default.
• W201797715 hasRelatedWork W2144344073 @default.
• W201797715 hasRelatedWork W2158870228 @default.
• W201797715 hasRelatedWork W2171222014 @default.
• W201797715 hasRelatedWork W2176418560 @default.
• W201797715 hasRelatedWork W2552322438 @default.
• W201797715 hasRelatedWork W296093612 @default.
• W201797715 hasRelatedWork W2974822644 @default.
• W201797715 hasRelatedWork W301837176 @default.
• W201797715 hasRelatedWork W3153363134 @default.
• W201797715 hasRelatedWork W643537044 @default.
• W201797715 hasRelatedWork W1593926850 @default.
• W201797715 hasRelatedWork W97798414 @default.
• W201797715 isParatext "false" @default.

• next